Caveolin-1: A tumor-promoting role in human cancer
Caveolin-1: A tumor-promoting role in human cancer
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DOI：
10.1080/09553000701745293
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发表时间：
2008-03-01
影响因子：
2.6
通讯作者：
Liscovitch, Mordechai
中科院分区：
文献类型：
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作者：
Shatz, Maria;Liscovitch, Mordechai
目的：小窝是非网格蛋白，瓶状的质膜内陷。小窝蛋白-I是小窝的基本成分，并且因此充当小窝依赖性脂质运输和内吞作用的调节剂。Caveolin-1与多种细胞蛋白相互作用并调节细胞信号传导事件。小窝蛋白-1似乎在癌症进展的早期阶段充当肿瘤抑制蛋白。然而，越来越多的证据表明，caveolin-1在几种多药耐药和转移性癌细胞系和人类肿瘤标本中上调。此外，caveolin-1水平与肿瘤分期和分级在许多癌症types.Conclusion：现有的实验数据支持caveolin-1在晚期癌症中的促肿瘤作用。
Purpose: Caveolae are non-clathrin, flask-shaped invaginations of the plasma membrane. Caveolin-l is an essential constituent of caveolae and as such acts as a regulator of caveolae-dependent lipid trafficking and endocytosis. Caveolin-1 interacts with a variety of cellular proteins and regulates cell-signaling events. Caveolin-l appears to act as a tumor suppressor protein at early stages of cancer progression. However, a growing body of evidence indicates that caveolin-1 is up-regulated in several multidrug-resistant and metastatic cancer cell lines and human tumor specimens. Furthermore, caveolin-1 levels are positively correlated with tumor stage and grade in numerous cancer types.Conclusion: The available experimental data support the tumor-promoting role of caveolin-1 in advanced-stage cancer.