Stimulation of repair in chronic, nonhealing, cutaneous ulcers using platelet-derived wound healing formula.
Stimulation of repair in chronic, nonhealing, cutaneous ulcers using platelet-derived wound healing formula.
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使用血小板衍生的伤口愈合配方刺激慢性、不愈合的皮肤溃疡的修复。
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
F. Cerra
中科院分区：
文献类型：
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作者：
D. Knighton;K. Ciresi;V. Fiegel;S. Schumerth;E. Butler;F. Cerra
慢性、无法愈合的皮肤溃疡是一个严重的临床问题。先前使用来自自体血小板的血小板衍生伤口愈合公式(PDWHF)的研究结果提供了证据，表明PDWHF积极促进伤口的修复。为了测试PDWHF是否加速修复，使用安慰剂对照进行了一项前瞻性随机、盲法试验。共有32名患有慢性、无法愈合的下肢皮肤创伤的患者被随机分为PDWHF组和安慰剂组，治疗8周。伤口上皮化是研究的终点。在接受治疗的组中，81%的患者在8周内上皮化，而对照组的这一比例为15%(p<0.0001)。交叉应用PDWHF治疗后，对照组全部患者上皮化时间平均为7.1周。回归分析显示，在最初的8周试验中，上皮化率也有显著差异，而在对照组与PDWHF交叉治疗后，上皮化率没有差异。这项研究的结果表明，局部应用血小板衍生生长因子对慢性、不可愈合的皮肤溃疡的修复具有非常显著的统计学意义。
Chronic, nonhealing, cutaneous ulcers are a serious clinical problem. The results of previous studies using platelet-derived wound healing formula (PDWHF), derived from autologous platelets, provided evidence that PDWHF actively stimulates repair of the wound. To test whether or not PDWHF accelerates repair, a prospectively randomized, blinded trial was conducted using a placebo control. A total of 32 patients with chronic, nonhealing, cutaneous wounds of the lower extremity were randomized and treated for eight weeks with PDWHF or placebo. Epithelialization of the wound was the end point of study. In the group who received treatment, 81 per cent of patients had epithelialization in eight weeks compared with 15 per cent in the control group (p less than 0.0001). After crossover to treatment with PDWHF, all of the patients in the control group had epithelialization in an average of 7.1 weeks. Regression analysis of the rates of epithelialization also showed significant differences during the initial eight week trial and showed no difference after crossover of the control group to therapy with PDWHF. Results from this study demonstrate a highly statistically significant effect of topically applied platelet-derived growth factors on the repair of chronic, nonhealing, cutaneous ulcers.