Perspective: The promise of multi-cellular engineered living systems
Perspective: The promise of multi-cellular engineered living systems
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DOI：
10.1063/1.5038337
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发表时间：
2018-12-01
影响因子：
6
通讯作者：
Zaman, Muhammad H.
中科院分区：
文献类型：
--
作者：
Kamm, Roger D.;Bashir, Rashid;Zaman, Muhammad H.
最近，我们在衍生和分化诱导多能干细胞、类器官生物学、器官芯片分析和 3D 生物打印方面取得的技术突破，都促使人们对具有广泛潜在用途的生命系统的设计、组装和制造产生了浓厚的兴趣。本白皮书总结了“多细胞工程生命系统”这一新兴领域的现状，该系统由相互作用的细胞群组成。描述了最近的成就，重点关注当前和潜在的应用，以及未来进步的障碍，以及需要考虑的长期利益的前景和潜在的道德问题。 (C) 2018 年作者。
Recent technological breakthroughs in our ability to derive and differentiate induced pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all contributed to a heightened interest in the design, assembly, and manufacture of living systems with a broad range of potential uses. This white paper summarizes the state of the emerging field of "multi-cellular engineered living systems," which are composed of interacting cell populations. Recent accomplishments are described, focusing on current and potential applications, as well as barriers to future advances, and the outlook for longer term benefits and potential ethical issues that need to be considered. (C) 2018 Author(s).