A study of idiopathic generalised epilepsy in an Irish population
A study of idiopathic generalised epilepsy in an Irish population
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DOI：
10.1016/j.seizure.2006.12.007
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发表时间：
2007-04-01
影响因子：
3
通讯作者：
Sweeney, B. J.
中科院分区：
文献类型：
--
作者：
Mullins, G. M.;O'Sullivan, S. S.;Sweeney, B. J.
特发性全身性癫痫（IGE）被细分为综合征的基础上的临床和EEG features.Purpose：本研究的目的是将所有情况下的IGE支持EEG异常的性别差异，癫痫发作类型报告，IGE综合征，癫痫家族史和EEG结果。我们还计算了有限的持续时间的流行IGE在我们的coherent.Methods：异常脑电图的数据收集回顾性从两个脑电图数据库在两个三级转诊中心的神经病学。结果：223例患者符合纳入标准，男性89例（39.9%），女性134例（60.1%）。强直阵挛性发作是最常见的发作类型，162例（72.65%）在某个时间有全身强直阵挛性发作（GTCS）。IGE伴单纯GTCS（EGTCSA）是我们队列中最常见的综合征，共有94例患者（34只雄性，60只雌性），42只（15名男性，27名女性）诊断为青少年肌阵挛性癫痫（JME）的患者，23名（9名男性，14名女性）患有青少年失神癫痫（JAE），（9男，11女）与儿童失神癫痫（CAE）。脑电图研究显示，在所有患者的全身性癫痫样activity.Conclusions：更多的女性比男性被诊断为全身性癫痫。强直阵挛性发作是报告的最常见的发作类型。EGTCSA是最常见的综合征。如以前报告的那样，性别差异在JAE和JME中很明显，在EGTCSA中也很明显，迄今为止没有报告，EGTCA和JME的性别差异达到了统计学意义。(c)2006年英国癫痫协会。由爱思唯尔有限公司出版。保留所有权利。
Idiopathic generalised epilepsy (IGE) is subdivided into syndromes based on clinical and EEG features.Purpose: The aim of this study was to characterise all cases of IGE with supportive EEG abnormalities in terms of gender differences, seizure types reported, IGE syndromes, family history of epilepsy and EEG findings. We also calculated the limited duration prevalence of IGE in our cohort.Methods: Data on abnormal EEGs were collected retrospectively from two EEG databases at two tertiary referral centres for neurology. Clinical information was obtained from EEG request forms, standardised EEG questionnaires and medical notes of patients.Results: two hundred twenty-three patients met our inclusion criteria, 89 (39.9%) mate and 134 (60.1%) females. Tonic clonic seizures were the most common seizure type reported, 162 (72.65%) having a generalised tonic clonic seizure (GTCS) at some time. IGE with GTCS only (EGTCSA) was the most common syndrome in our cohort being present in 94 patients (34 mate, 60 female), with 42 (15 mate, 27 female) patients diagnosed with Juvenile myoclonic epilepsy (JME), 23 (9 mate, 14 female) with Juvenile absence epilepsy (JAE) and 20 (9 mate, 11 female) with childhood absence epilepsy (CAE).EEG studies in all patients showed generalised epileptiform activity.Conclusions: More women than men were diagnosed with generalised epilepsy. Tonic clonic seizures were the most common seizure type reported. EGTCSA was the most frequent syndrome seen. Gender differences were evident for JAE and JME as previously reported and for EGTCSA, which was not reported to date, and reached statistical significance for EGTCA and JME. (c) 2006 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.