Living and thriving on the skin: Malassezia genomes tell the story.
Living and thriving on the skin: Malassezia genomes tell the story.
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DOI：
10.1128/mbio.00117-13
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发表时间：
2013-03-19
期刊：
影响因子：
6.4
通讯作者：
Gonçalves P
中科院分区：
文献类型：
--
作者：
Coelho MA;Sampaio JP;Gonçalves P
最近的研究极大地扩展了我们对正常皮肤微生物群与人类宿主之间相互作用的理解。在他们最近在mBio上的研究中，A. Gioti等人（mBio 4[1]：e00572-12，2013）对特应性湿疹相关酵母合轴马拉色菌的基因组进行了测序，并将其基因内容和组织与头皮屑相关的马拉色菌（Malassezia globosa）进行了比较。他们的研究结果也与先前获得的玉米黑粉菌（Ustilago maydis）的研究结果进行了对比，玉米黑粉菌是一种近亲但生态学上不同的植物寄生虫。除了获得对关键宿主特异性适应以及与特应性湿疹相关的过敏原的特定功能和分子进化的额外见解外，Gioti等人还发现了几条证据，这些证据优雅地表明存在现存的性周期，对疾病具有重要意义。
Our understanding of the interactions between normal skin microbiota and the human host has been greatly extended by recent investigations. In their recent study in mBio, A. Gioti et al. (mBio 4[1]:e00572-12, 2013) sequenced the genome of the atopic eczema-associated yeast, Malassezia sympodialis, and compared its gene content and organization with that of Malassezia globosa, a species implicated in dandruff. Their findings were also contrasted with those previously obtained for Ustilago maydis, which is a close relative but ecologically distinct plant parasite. Besides gaining additional insight into key host-specific adaptations and the particular function and molecular evolution of allergens related to atopic eczema, Gioti et al. also uncovered several lines of evidence that elegantly suggest the presence of an extant sexual cycle, with important implications in disease.