DIET AND SERUM-CHOLESTEROL - DO ZERO CORRELATIONS NEGATE THE RELATIONSHIP
DIET AND SERUM-CHOLESTEROL - DO ZERO CORRELATIONS NEGATE THE RELATIONSHIP
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DOI：
10.1093/oxfordjournals.aje.a112791
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发表时间：
1979-01-01
影响因子：
5
通讯作者：
BLACKBURN, H
中科院分区：
文献类型：
--
作者：
JACOBS, DR;ANDERSON, JT;BLACKBURN, H
大多数流行病学观察是在不受控制的条件下进行的，这种情况造成的混淆足以破坏它们在调查饮食和血清胆固醇之间关系方面的有效性。使用数学模型和参考经验数据，如果某些方差足够大，即使存在因果关系，从横断面研究的实际数据中可以预期相关系数接近于零。横断面设计不适合研究这种关系。这项研究与心脏病流行病学有关。
The confounding that results from the uncontrolled conditions under which most epidemiologic observations are made is sufficient to undermine their validity with respect to investigation of the relationship between diet and serum cholesterol. Using both a mathematical model and referring to empirical data, if certain variances are sufficiently great, even when there is cause and effect, correlation coefficients close to zero would be expected from the actual data of a cross-sectional study. Cross-sectional designs are not suitable for studying this relationship. [This study is relevant to heart attack epidemiology.].