Arterial compliance in patients on long-treatment-time dialysis
Arterial compliance in patients on long-treatment-time dialysis
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DOI：
10.1093/ndt/12.12.2629
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发表时间：
1997-12-01
影响因子：
6.1
通讯作者：
Leunissen, KML
中科院分区：
文献类型：
--
作者：
Luik, AJ;Spek, JJ;Leunissen, KML
Arterial compliance is found to be reduced in haemodialysis patients. It is not clear whether decreased arterial compliance in uraemic patients is a consequence of long-standing increased mean arterial blood pressure or a consequence of the uraemic state. An adequate blood pressure can be achieved by long-treatment-time dialysis of 8 h three times a week. We studied femoral and carotid artery wall properties in 24 normotensive patients on long-treatment-time dialysis and 24 normal controls matched for mean arterial pressure, age, sex, and body mass index. Arterial distensibility coefficient and compliance coefficient were determined with a vessel wall movement detector system, 24 h after dialysis in the supine position.The patients were 5.9+/-6.6 years on long-treatment-time dialysis at a Kt/V of 1.8+/-0.4. We found no significant differences in mean arterial pressure or pulse pressure between patients (85+/-13, 55+/-17 mmHg) and controls (84+/-6, 50+/-13 mmHg). Femoral distensibility coefficient and compliance coefficient were lower in patients (6.0+/-2.4 10(-3)/kPa; P < 0.05, 0.52+/-0.28 mm(2)/kPa; n.s.) compared to the controls (8.8+/-4.0 10(-3)/kPa, 0.67+/-0.38 mm(2)/kPa). No differences in carotid distensibility coefficient and compliance coefficient were found between patients (12.8+/-4.6 10(-3)/kPa, 0.72+/-0.30 mm(2)/kPa) and controls (14.1+/-4.4 10(-3)/kPa, 0.70+/-0.23 mm(2)/kPa).We conclude that patients on long-treatment-time-dialysis have an increased stiffening of the muscular femoral artery but not of the more elastic carotid artery. Results suggest that the uraemic state itself has a deleterious effect on the elastic properties of the muscular femoral artery.
