Development and impact of human papillomavirus vaccines.
Development and impact of human papillomavirus vaccines.
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人乳头瘤病毒疫苗的开发和影响。
DOI：
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发表时间：
2013
影响因子：
1.5
通讯作者：
Jennifer J Mueller
中科院分区：
文献类型：
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作者：
C. Darus;Jennifer J Mueller
宫颈癌是一种全球性的健康危机，对发展中国家和得不到充分服务的人口造成了不成比例的影响。两种靶向HPV-16和18的疫苗，占浸润性宫颈癌的70%，在美国和全球许多国家获得许可。两种疫苗制剂均显示出优异的功效和最小的毒性。许多问题仍然存在，包括成本效益，男性疫苗接种，HPV疫苗接种的社会接受程度，以及HPV免疫人群的宫颈发育不良筛查。在发达国家和资源贫乏的国家，为得不到充分服务的人口接种疫苗仍然是一个问题。包含其他致癌HPV毒株的多价疫苗正在开发中。
Cervical cancer is a global health crisis that disproportionately affects developing nations and underserved populations. Two vaccines targeting HPV-16 and 18, which account for 70% of invasive cervical carcinomas, are licensed in the United States and numerous countries worldwide. Both vaccine formulations have shown excellent efficacy with minimal toxicity. Numerous questions remain, including cost-effectiveness, vaccination of males, societal acceptance of HPV vaccination, and cervical dysplasia screening in the HPV-immunized population. Access to vaccination for underserved populations both in developed and resource-poor nations remains an issue. Multivalent vaccines that encompass additional oncogenic HPV strains are under development.
DOI：
10.1056/nejmoa0909537
发表时间：
2011-02-03
期刊：
The New England journal of medicine
影响因子：
--
作者：
Giuliano AR;Palefsky JM;Goldstone S;Moreira ED Jr;Penny ME;Aranda C;Vardas E;Moi H;Jessen H;Hillman R;Chang YH;Ferris D;Rouleau D;Bryan J;Marshall JB;Vuocolo S;Barr E;Radley D;Haupt RM;Guris D
通讯作者：
Guris D