MicroRNA signatures in liver diseases
MicroRNA signatures in liver diseases
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DOI：
10.3748/wjg.15.1665
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发表时间：
2009-04-14
影响因子：
4.3
通讯作者：
Chen, Xian-Ming
中科院分区：
文献类型：
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作者：
Chen, Xian-Ming
MicroRNAs （miRNAs）是一类新兴的高度保守的非编码小rna，在转录后水平调控基因表达。现在很清楚，mirna可以潜在地调节细胞活动的各个方面，包括分化和发育、代谢、增殖、凋亡细胞死亡、病毒感染和肿瘤发生。最近的研究提供了明确的证据，表明mirna在肝脏中丰富，并调节多种肝功能。miRNA表达的失调可能是病毒性肝炎、肝细胞癌和多囊性肝病等多种肝脏疾病的关键致病因素。更清楚地了解miRNA失调的机制将为治疗肝脏疾病提供新的诊断和治疗策略。此外，更好地了解miRNA调控和利用转基因/敲除模型和/或调节寡核苷酸鉴定组织特异性miRNA靶点将提高我们对肝脏生理和疾病的认识。(C) 2009 WJG出版社和白石登出版社。版权所有。
MicroRNAs (miRNAs) are an emerging class of highly conserved non-coding small RNAs that regulate gene expression at the post-transcriptional level. It is now clear that miRNAs can potentially regulate every aspect of cellular activity, including differentiation and development, metabolism, proliferation, apoptotic cell death, viral infection and tumorigenesis. Recent studies provide clear evidence that miRNAs are abundant in the liver and modulate a diverse spectrum of liver functions. Deregulation of miRNA expression may be a key pathogenetic factor in many liver diseases including viral hepatitis, hepatocellular cancer and polycystic liver diseases. A clearer understanding of the mechanisms involved in miRNA deregulation will offer new diagnostic and therapeutic strategies to treat liver diseases. Moreover, better understanding of miRNA regulation and identification of tissue-specific miRNA targets employing transgenic/knockout models and/or modulating oligonucleotides will improve our knowledge of liver physiology and diseases. (C) 2009 The WJG Press and Baishideng. All rights reserved.