EFFECT OF REPLACEMENT OF METHIONINE BY HOMOCYSTINE ON SURVIVAL OF MALIGNANT AND NORMAL ADULT MAMMALIAN-CELLS IN CULTURE
EFFECT OF REPLACEMENT OF METHIONINE BY HOMOCYSTINE ON SURVIVAL OF MALIGNANT AND NORMAL ADULT MAMMALIAN-CELLS IN CULTURE
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DOI：
10.1073/pnas.71.4.1133
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发表时间：
1974-01-01
影响因子：
11.1
通讯作者：
SMITH, RA
中科院分区：
文献类型：
--
作者：
HALPERN, BC;CLARK, BR;SMITH, RA
在正常成体和恶性哺乳动物细胞的组织培养中，在富含叶酸和氰钴胺素的培养基中，同型半胱氨酸已取代蛋氨酸。正常的成体细胞会茁壮成长。来自包括人类在内的三个不同物种的三种高度恶性细胞类型死亡。
In tissue cultures of normal adult and malignant mammalian cells, homocystine has been substituted for methionine in a medium rich in folic acid and cyanocobalamin. Normal adult cells thrive. Three highly malignant cell types from three different species, including man, die.