Effect of menstrual cycle on rewarding properties of alcohol cues in women.
Effect of menstrual cycle on rewarding properties of alcohol cues in women.
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月经周期对女性酒精暗示的奖励特性的影响。
DOI：
10.1037/adb0000978
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Fillmore,MarkT
中科院分区：
文献类型：
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作者：
Griffith,AnnieK;Martel,MichelleM;Fillmore,MarkT
目的与男性相比，女性受酒精的影响更大，包括行为障碍和戒酒治疗复发的风险更大。这种差异背后的一个潜在机制是月经周期各个阶段的卵巢激素波动，尤其是雌二醇 (E2)。临床前和临床研究表明，E2 水平与饮酒量呈正相关，表明 E2 可以调节饮酒。酒精的奖励特性被认为可以调节这种关系。本研究测试了在月经周期末期卵泡期 E2 升高时，女性报告的酒精奖励效应增加以及对酒精相关线索的注意力增强的程度。方法 50 名 21-29 岁的女性参加了一项受试者内安慰剂对照研究，研究月经周期阶段如何改变清醒和醉酒时酒精和酒精相关线索的奖励特性，通过她们对酒精相关线索和主观报告的注意力偏差来衡量。测量结果是在卵泡早期（E2 较低）和卵泡晚期（即排卵）E2 升高时服用 0.60 g/kg 酒精和安慰剂后获得的。结果在卵泡晚期，无论是清醒状态还是醉酒状态，对酒精相关线索的注意力偏差都更大。女性报告了酒精的奖励作用，但没有观察到相位的影响。结论研究结果表明，在月经周期的卵泡晚期，当 E2 升高时，与酒精相关的线索的奖励特性可能会增强，可能会增加女性在此阶段过度饮酒的风险。（PsycInfo 数据库记录 (c) 2024 APA，保留所有权利）
ObjectiveCompared with men, women are disproportionately affected by alcohol, including greater risks of behavioral impairment and relapse from abstinence-based treatments. One potential mechanism underlying this disparity is ovarian hormone fluctuations across menstrual cycle phases, particularly estradiol (E2). Preclinical and clinical studies have shown that E2 levels positively correlate with alcohol consumption, suggesting E2 modulates drinking. Rewarding properties of alcohol are thought to mediate this relationship. The present study tested the degree to which women report increased rewarding effects from alcohol and heightened attention to alcohol-related cues when E2 was elevated during the late follicular phase of the menstrual cycle.MethodFifty women aged 21–29 participated in a within-subjects placebo-controlled study examining how menstrual cycle phase alters the rewarding properties of alcohol and alcohol-associated cues when sober and intoxicated, as measured by their attentional bias toward alcohol-associated cues and subjective reports. Measures were obtained following 0.60 g/kg alcohol and placebo during the early follicular phase when E2 was low and the late follicular phase (ie, ovulation) when E2 was elevated.ResultsAttentional bias to alcohol-associated cues was greater during the late follicular phase in both sober and intoxicated states. Women reported rewarding effects from alcohol, but no effects of phase were observed.ConclusionsThe findings suggest that the rewarding properties of alcohol-associated cues might be enhanced during the late follicular phase of the menstrual cycle when E2 is elevated, possibly increasing the risk for excessive drinking in women during this phase.(PsycInfo Database Record (c) 2024 APA, all rights reserved)