Genome sequence-independent identification of RNA editing sites.
Genome sequence-independent identification of RNA editing sites.
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DOI:
10.1038/nmeth.3314
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发表时间:
2015-04
期刊:
影响因子:
48
通讯作者:
Xiao, Xinshu
中科院分区:
文献类型:
--
作者:
Zhang, Qing;Xiao, Xinshu
High-throughput RNA sequencing (RNA-Seq) provides single-nucleotide information that makes it a powerful tool for prediction of RNA editome. A new method, GIREMI, predicts RNA editomes (mainly A-to-I editing) accurately and sensitively using a single RNA-Seq data set, which does not require sample-specific genome sequence data or high sequencing depth. Using GIREMI, we observed prevailing tissue-specificity of RNA editing and interesting evolutionary patterns of editing sites in human population.
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