Shiga toxin of enterohemorrhagic Escherichia coli type O157:H7 promotes intestinal colonization
Shiga toxin of enterohemorrhagic Escherichia coli type O157:H7 promotes intestinal colonization
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DOI：
10.1073/pnas.0602359103
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发表时间：
2006-06-20
影响因子：
11.1
通讯作者：
O'Brien, Alison D.
中科院分区：
文献类型：
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作者：
Robinson, Cory M.;Sinclair, James F.;O'Brien, Alison D.
肠出血性大肠杆菌（EHEC）O 157：117是一种食源性病原体，可引起出血性腹泻，偶尔也会因该微生物产生滋贺毒素（Stx）而导致急性肾衰竭。stx是一种强效的细胞毒素，在低剂量下对动物致命。因此，Stxs不仅伤害宿主，而且还显著增强EHEC O157：117粘附上皮细胞和定植小鼠肠道的能力。组织培养实验表明，这种毒素介导的细菌粘附的增加与Stx诱发的EHEC O157：117粘附因子intimin的真核受体的增加相关。
Enterohemorrhagic Escherichia coli (EHEC) O157:117 is a food-borne pathogen that can cause bloody diarrhea and, occasionally, acute renal failure as a consequence of Shiga toxin (Stx) production by the organism. Stxs are potent cytotoxins that are lethal to animals at low doses. Thus, Stxs not only harm the host but, as reported here, also significantly enhance the capacity of EHEC O157:117 to adhere to epithelial cells and to colonize the intestines of mice. Tissue culture experiments showed that this toxin-mediated increase in bacterial adherence correlated with an Stx-evoked increase in a eukaryotic receptor for the EHEC O157:117 attachment factor intimin.