ACUTE EFFECTS OF COLD ON BLOOD-PRESSURE, RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, CATECHOLAMINES AND ADRENAL-STEROIDS IN MAN
ACUTE EFFECTS OF COLD ON BLOOD-PRESSURE, RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, CATECHOLAMINES AND ADRENAL-STEROIDS IN MAN
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DOI：
10.1111/j.1440-1681.1984.tb00254.x
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发表时间：
1984-01-01
影响因子：
2.9
通讯作者：
KATAKURA, M
中科院分区：
文献类型：
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作者：
HIRAMATSU, K;YAMADA, T;KATAKURA, M
1.为了研究寒冷对血压和肾素-血管紧张素-醛固酮系统的影响，34名有或没有原发性高血压家族史的健康年轻受试者暴露于中度寒冷（4°C持续1小时）或重度寒冷（双手浸入0°C持续10分钟）。当受试者穿着夏季服装时，中度寒冷会升高血压、醛固酮、皮质醇和去甲肾上腺素，而当受试者穿着冬季服装时则不会。无论穿什么样的衣服，皮肤血流量和血浆肾素活性在中度寒冷时显著降低，但血管紧张素II的降低不显著。严寒使血压、皮质醇、醛固酮和去甲肾上腺素升高。地塞米松的管理显着抑制增加的醛固酮和皮质醇在寒冷的反应，但未能影响血压和去甲肾上腺素的升高。血浆肾素活性和血管紧张素II浓度在冷应激过程中和冷应激后均未受到影响.有人建议，在研究的各种激素中，去甲肾上腺素是唯一一种负责血压升高的激素。
1. In an attempt to study effects of cold on blood pressure and the reninangiotensin‐aldosterone system, 34 healthy young subjects with or without a family history of essential hypertension were exposed to moderate cold (4°C for 1 h) or severe cold (immersion of the hands to 0°C for 10 min). Moderate cold elevated blood pressure, aldosterone, cortisol and noradrenaline when the subjects wore summer clothing but not when the subjects wore winter clothing. Regardless of the clothing worn, skin blood flow and plasma renin activity decreased significantly in response to moderate cold but angiotensin II decreased insignificantly.2. Severe cold elevated blood pressure, cortisol, aldosterone and noradrenaline. Administration of dexamethasone significantly depressed an increase of aldosterone and cortisol in response to cold but failed to effect an elevation of blood pressure and noradrenaline. Plasma renin activity and angiotensin II concentration were not affected at all during and after cold exposure.3. It is suggested that, among the various hormones studied, noradrenaline is the only hormone responsible for an elevation of blood pressure in response to cold.