Assessment of liver fibrosis using T1 mapping on Gd-EOB-DTPA-enhanced magnetic resonance
Assessment of liver fibrosis using T1 mapping on Gd-EOB-DTPA-enhanced magnetic resonance
复制标题
使用 Gd-EOB-DTPA 增强磁共振 T1 映射评估肝纤维化
DOI：
10.1016/j.dld.2017.02.006
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发表时间：
2017-07-01
影响因子：
4.5
通讯作者：
Zeng, Meng Su
中科院分区：
文献类型：
--
作者：
Sheng, Ruo Fan;Wang, He Qing;Zeng, Meng Su
背景资料：Gd-EOB-DTPA增强T1显像对肝纤维化分期的诊断价值及其与肝分子转运蛋白的相关性研究较少，目的：探讨Gd-EOB-DTPA增强T1显像对肝纤维化分期的诊断价值及其与肝分子转运蛋白的关系。在Gd-EOB-DTPA给药前和给药后20 min进行T1标测。结果：肝胆相T1弛豫时间（HBP）和Delta%在各相邻肝纤维化亚组间差异有统计学意义（P=0.000-0.042）;纤维化与HBP和Delta%之间存在非常强的相关性（r=0.960/-0.952），多变量分析显示，与坏死炎症活动和铁负荷相比，纤维化是HBP（P=0.000）和Delta%（P=0.001）独立预测的唯一因素。有机阴离子转运多肽（Oatplal）的表达与HBP和Delta%在mRNA（r=-0.741/0.697）和蛋白质（r=-0.577/0.602）水平上均呈显著相关。多药耐药相关蛋白2（Mrp 2）的相关性较弱。结论：Gd-EOB-DTPA增强T1显像可作为肝纤维化分期的可靠诊断工具，也可作为肝细胞转运蛋白功能的影像学标志物。(C)2017 Editrice Gastroenterologica Italiana S.r.l.由爱思唯尔有限公司出版。保留所有权利。
Background: Few studies have investigated the value of Gd-EOB-DTPA-enhanced T1 mapping in exact fibrosis staging, especially its correlation with hepatic molecular transporters.Aims: To investigate the diagnostic value of Gd-EOB-DTPA-enhanced T1 mapping in staging liver fibrosis and its relationship with hepatic molecular transporters.Methods: Thirty rats were divided into the carbon tetrachloride-induced fibrosis groups and a control group. Tl-mapping was performed before and 20 min after administration of Gd-EOB-DTPA. The T1 relaxation time and reduction rate (Delta%) were calculated, and their correlations with the degree of fibrosis, necroinflammatory activity, iron load and hepatic molecular transporters were assessed and compared.Results: Hepatobiliary phase T1 relaxation time (HBP) and Delta% were different between each adjacent fibrosis subgroups(P=0.000-0.042). Very strong correlations existed between fibrosis and both HBP and Delta% (r=0.960/-0.952), and multivariate analyses revealed that fibrosis was the only factor independently predicted by HBP (P=0.000) and Delta% (P=0.001), comparing to necroinflammatory activity and iron load. The expression of the organic anion transporting polypeptidelal (Oatplal) was significantly correlated with HBP and Delta% at both mRNA (r=-0.741/0.697) and protein (r=-0.577/0.602) levels. Weaker correlations were found for multidrug resistance associated protein2 (Mrp2). Generally, both transporters showed decreasing levels with increasing degrees of fibrosis.Conclusion: Gd-EOB-DTPA-enhanced T1 mapping may provide a reliable diagnostic tool in staging liver fibrosis, and can be regarded as a useful imaging biomarker of hepatocyte transporter function. (C) 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.