Sensitivity, specificity, and positive predictivity of the Hemoccult test in screening for colorectal cancers. The University of Minnesota's Colon Cancer Control Study.
Sensitivity, specificity, and positive predictivity of the Hemoccult test in screening for colorectal cancers. The University of Minnesota's Colon Cancer Control Study.
复制标题
血隐试验在结直肠癌筛查中的敏感性、特异性和阳性预测率。
DOI：
10.1016/0016-5085(89)90629-x
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发表时间：
1989
期刊：
影响因子：
29.4
通讯作者：
Gilbertsen,V
中科院分区：
文献类型：
--
作者：
Mandel,JS;Bond,JH;Bradley,M;Snover,DC;Church,TR;Williams,S;Watt,G;Schuman,LM;Ederer,F;Gilbertsen,V
根据明尼苏达州结肠癌控制研究的经验，提供了关于隐血试验的敏感度、特异度和阳性预测性的数据，该研究是一项随机临床试验，旨在确定使用隐血试验是否可以降低结直肠癌的死亡率。在处理前用一滴水重新水化载玻片，可提高阳性(2.4%至9.8%)和敏感性(80.8%至92.2%)，但特异性(97.7%至90.4%)和阳性预测性(5.6%至2.2%)下降。并对年龄、性别等因素的影响进行了评价。这项测试对男性的特异性低于女性(p=0.03)。特异度在60岁以上者最高，随年龄增长而降低(p=0.05)。随着年龄的增长，阳性预测性从60岁以下的1.6%增加到70岁以上的3.6%(p=0.0004)。
Data are presented on the sensitivity, specificity, and positive predictivity of the Hemoccult test based on the experience of the Minnesota Colon Cancer Control Study, a randomized clinical trial to determine whether the use of the Hemoccult test can reduce mortality from colorectal cancer. Rehydrating the slides with a drop of water before processing resulted in an increase in positivity (2.4% to 9.8%), and sensitivity (80.8% to 92.2%) but a decrease in specificity (97.7% to 90.4%) and positive predictivity (5.6% to 2.2%). The effects of age and sex were also evaluated. The test was less specific for men than women (p = 0.03). Specificity was highest for those < 60 yr of age and decreased with increasing age (p = 0.05). The positive predictivity increased with age from 1.6% for those under 60 yr to 3.6% for those over 70 yr (p = 0.0004).