Coupling between lumbar and sacral motor networks in the neonatal rat spinal cord
Coupling between lumbar and sacral motor networks in the neonatal rat spinal cord
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DOI：
10.1046/j.1460-9568.2000.00169.x
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发表时间：
2000-08-01
影响因子：
3.4
通讯作者：
Bertrand, S
中科院分区：
文献类型：
--
作者：
Cazalets, JR;Bertrand, S
我们已经研究了节奏产生能力的腰椎，骶骨和尾骨（CO）地区使用一个孤立的脊髓制备的新生大鼠。将N-甲基-D-L-天冬氨酸（NMA）和5-羟色胺（5-HT）的混合物在整个脊髓上浴应用，诱导了从腰椎到尾椎前根的协调节律活动。分析了头侧腰段和骶段活动之间的相位关系和平均爆发持续时间。通过使用切片或选择性药理学激活直接激活骶骨网络，表明这些尾段具有自身的节律发生能力。通过结合切片实验和脊髓区室化，我们证明了腰骶运动网络之间存在强耦合。此外，我们发现在完整的脊髓中，骶神经网络的活动是由腰神经网络驱动的。我们已经发现，腰椎和骶骨活动之间可能会出现不同的协调模式。最后，我们已经表明，腰骶神经网络之间的耦合可以通过感觉输入进行修改，这表明脊髓机制可以调节和适应这两个脊髓网络的耦合。
We have studied the rhythm-generating capabilities of the lumbar, sacral and coccygeal (Co) areas using an isolated spinal cord preparation of the newborn rat. The bath-application of a mixture of N-methyl-D-L-aspartate (NMA) and serotonin (5-HT) on the whole spinal cord induced a coordinated rhythmic activity that could be recorded from the lumbar to the coccygeal ventral roots. The phase relationships and mean burst duration between the activity in the rostral lumbar segments and the activity in the sacral segments was analysed. The direct activation of the sacral network, by using sections or by selective pharmacological activation, showed that these caudal segments possess their own rhythmogenic capability. By combining section experiments and compartmentation of the spinal cord, we demonstrated that a strong coupling exists between the lumbar and sacral motor networks. In addition, we found that in an intact spinal cord the activity of the sacral networks is driven by the lumbar networks. We have found that different modes of coordination between the lumbar and the sacral activity may occur. Finally, we have shown that the coupling between the lumbar and sacral networks can be modified by sensory inputs, suggesting that the spinal machinery could modulate and adapt the coupling of these two spinal networks.