Effectiveness of Short Term Percutaneous Tibial Nerve Stimulation for Non-neurogenic Overactive Bladder Syndrome in Adults: A Meta-analysis.
Effectiveness of Short Term Percutaneous Tibial Nerve Stimulation for Non-neurogenic Overactive Bladder Syndrome in Adults: A Meta-analysis.
复制标题
短期经皮胫神经刺激对成人非神经源性膀胱过度活动综合症的有效性：荟萃分析。
作者：
Elita Wibisono;H. Rahardjo
目标
通过与Sham手术和其他治疗方法的比较，系统评价短期PTNS治疗成人非神经源性OAB的疗效。
方法
我们对队列研究进行了系统回顾。数据来源是MEDLINE、EMBASE、CINAHL、国家健康图书馆、Cochrane和谷歌学者。采用随机效应模型进行Meta分析。通过计算I2统计量来评估效应的异质性。使用Review Manager 5.3进行随机对照试验Meta分析进行统计分析。
结果
我们分析了11个随机对照试验(RCT)和5个具有可变成功率的前瞻性非比较研究。根据应答者的百分比，PTNS组为37.3%~81.8%，假手术组为0%~20.9%，抗毒鼠宁组为54.8%，多模组为89.7%。PTNS组(0.7~4.5次)、假手术组(0.3~1.5次)和抗毒扁豆碱组(0.6~2.9次)每日排尿症状次数明显减少。在四项随机对照试验的Meta分析中，PTNS优于Sham手术，总体风险比为7.32(95%CI为1.69-32.16)，p=0.09，I2=54%。
结论
有证据表明，短期PTNS治疗非神经源性OAB是有效的。PTNS被证明明显好于Sham手术。
AIM
to evaluate the effectiveness of short-term PTNS for non-neurogenic OAB in adults systematically by comparing with sham procedure and other treatments.
METHODS
we performed a systematic review of cohort study. Data sources were MEDLINE, EMBASE, CINAHL, National Library for Health, Cochrane, and google scholar from 2005 through 2015. Meta-analysis was performed using the random effects model. Heterogeneity of effects was assessed by calculating I2 statistic. Statistical analysis was performed using Review Manager 5.3 for RCT meta-analysis.
RESULTS
we analized 11 randomised controlled trial (RCT) and five prospective non-comparative studies with variable success rate. Based on percentage of responders, the results were 37.3% - 81.8% in PTNS group, 0% - 20.9% in sham group, 54.8% in anti-muscarinic group, and 89.7% in multimodal group. The decrease of voiding symptoms episodes per day was found in PTNS (0.7-4.5), sham (0.3-1.5), and anti-muscarinic (0.6-2.9) groups. In meta-analysis of four RCTs, the results favour PTNS over sham procedure with overall risk ratio of 7.32 (95% CI of 1.69-32.16), p=0.09, I2=54%.
CONCLUSION
there is an evidence of effectiveness of short term PTNS in treatment of non-neurogenic OAB. PTNS is proven significantly better than sham procedure.