Elevated tumour markers prior to complete tumour removal in patients with pseudomyxoma peritonei predict early recurrence
Elevated tumour markers prior to complete tumour removal in patients with pseudomyxoma peritonei predict early recurrence
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DOI：
10.1111/j.1463-1318.2005.00773.x
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发表时间：
2005-07-01
影响因子：
3.4
通讯作者：
Moran, B
中科院分区：
文献类型：
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作者：
Alexander-Sefre, F;Chandrakumaran, K;Moran, B
目的：评价术前CEA、ca125和ca19 -9对腹腔假性粘液瘤（PMP）患者在完全细胞减缩手术和腹腔内化疗后复发风险的潜在价值。方法：在1996年3月至2001年10月期间，35例患者进行了完全的细胞减少，术前记录了肿瘤标志物测量。记录32例幸存者的预后。结果：中位年龄53岁（范围32-74岁）。雌性17只（53%）。9/32[28%]投票率指标均正常。最常见的异常是CEA水平升高（14/32）[44%]。中位随访时间为23个月（范围：11-74）。8/32例复发[25%]。CEA升高组2年无复发间期为53%，而CEA正常组为94%。术前标记正常的9例患者2年无病间隔为100%，而至少有一项异常标记的组为66%。结论：CEA升高的PMP患者，或不止一个异常的血清抗原，有复发的危险。
Objective: To assess the potential value of pre-operative CEA, CA 125 and CA 19-9 in identifying Pseudornyxoma peritonei (PMP) patients at risk of recurrence following complete cytoreductive surgery and intraperitoneal chemotherapy.Method: Between March 1996 and October 2001, 35 patients, with documented pre-operative tumour marker measurements, underwent complete cytoreduction. Outcome in the 32 survivors was recorded.Results: Median age was 53 years (range: 32-74). There were 17[53%] females. In 9/32[28%] all turnout markers were normal. The most common abnormality was elevated CEA level in 14/32[44%]. Median follow up was 23 months (range: 11-74). Recurrence was detected in 8/32[25%]. The 2-year recurrence free interval was 53% in those with elevated CEA compared with 94% with normal CEA. The 2-year disease free intervals were 100% in 9 patients with normal preop markers compared with 66% for the group with at least one abnormal marker.Conclusion: PMP patients with elevated CEA, or more than one abnormal serum turnout maker, are at risk of developing recurrent disease.