Pancreatic β-cell glucokinase -: Closing the gap between theoretical concepts and experimental realities
Pancreatic β-cell glucokinase -: Closing the gap between theoretical concepts and experimental realities
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DOI：
10.2337/diabetes.47.3.307
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发表时间：
1998-03-01
期刊：
影响因子：
7.7
通讯作者：
Magnuson, MA
中科院分区：
文献类型：
--
作者：
Matschinsky, FM;Glaser, B;Magnuson, MA
在胰腺β细胞葡萄糖激酶-葡萄糖传感器的酶动力学和生化遗传学方面，理论概念和实验现实之间仍然存在很大差距。许多实验室目前努力的目标是弥合这一差距。这一观点旨在提供一个及时的审查这一关键方面的研究，葡萄糖稳态。它简要地处理葡萄糖激酶酶动力学的一些基本原理，提供了一些相关的生物化学遗传学考虑，通过强调人类研究和参考最近的小鼠研究来评估该领域的当前实验数据库，并对这一奋进的未来进行了一些推断。
There remains a wide gap between theoretical concepts and experimental realities in the enzyme kinetics and biochemical genetics of the pancreatic beta-cell glucokinase-glucose sensor. It is the goal of present efforts in many laboratories to bridge this gap. This perspective intends to provide a timely review of this crucial aspect of research in glucose homeostasis. It deals briefly with some fundamentals of glucokinase enzyme kinetics, offers some pertinent biochemical genetic considerations, takes stock of the current experimental database of the field by emphasizing human studies and referring to recent mouse studies, and ventures a few extrapolations into the future of this endeavor.