Results of surgical resection of patients with primary lung cancer: A retrospective analysis of 1,905 cases
Results of surgical resection of patients with primary lung cancer: A retrospective analysis of 1,905 cases
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DOI：
10.1016/s0003-4975(01)02932-0
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发表时间：
2001-10-01
影响因子：
4.6
通讯作者：
Zhang, DC
中科院分区：
文献类型：
--
作者：
Fang, DK;Zhang, DW;Zhang, DC
背景。手术切除、联合治疗和淋巴结切除术被广泛应用于肺癌患者的治疗。本研究总结了原发性肺癌患者单独手术切除或联合辅助治疗后的临床资料，并对影响其长期生存的主要因素进行了评价。对1961年3月至1995年12月在中国医学科学院癌症研究所连续治疗的1905例原发性肺癌患者进行回顾性分析。采用STATA软件进行统计分析。生存率采用生命表法估算。生存差异采用log-rank检验。采用改良的1997 TNM分期系统。在我们的研究中，发病率为12.28%，住院死亡率为1.31%。完全切除的5年生存率为49.5%，姑息性切除的5年生存率为18.8% （p < 0.01）。IA期5年生存率为72.0%，IB期为61.0% (p < 0.05)， IIA期为32.9%，IIB期为34.5%，IIIA期为22.6%，IIIB期为15.9% (p < 0.05)， iv期为7.1%。多种因素影响原发性肺癌术后患者的长期生存。它们包括TNM分期、手术切除程度（完全或姑息性）、切除边缘（阳性或阴性）、肿瘤的病理类型和切除类型。(C) 2001年由胸外科医生协会。
Background. Surgical resection, combined therapies, and lymphadenectomy are extensively utilized in the treatment of patients with lung cancer. In the present study, we summarized the clinical data of patients with primary lung cancer after surgical resection alone or combined with adjuvant therapy, and evaluate the main factors influencing long-term survival.Methods. A retrospective review of 1,905 consecutive patients with primary lung cancer treated at the Cancer Institute of the Chinese Academy of Medical Sciences from March 1961 through December 1995 was performed. Statistical analysis was done using STATA software. The survival rate was estimated using the life-table method. Survival differences were performed using the log-rank test. The modified 1997 TNM staging system was used.Results. There was a 12.28% morbidity rate and a 1.31% hospital mortality in our series. The 5-year survival rate for the complete resection was 49.5% and for the palliative resection 18.8% (p < 0.01). The 5-year survival rate was 72.0% in stage IA and 61.0% in stage IB (p < 0.05), 32.9% in stage IIA and 34.5% in stage IIB, 22.6% in stage IIIA and 15.9% in stage IIIB (p < 0.05), and 7.1% in stage IV.Conclusions. Multiple factors influence the long-term survival of patients with primary lung cancer after surgery. They include TNM staging, the extent of surgical resection (complete or palliative), resection margin (positive or negative), pathologic type of tumors, and type of resection. (C) 2001 by The Society of Thoracic Surgeons.