A reconsideration of the Campylobacter dose-response relation
A reconsideration of the Campylobacter dose-response relation
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DOI：
10.1017/s0950268805003912
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发表时间：
2005-08-01
影响因子：
4.2
通讯作者：
Van Pelt, W
中科院分区：
文献类型：
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作者：
Teunis, P;Van den Brandhof, W;Van Pelt, W
空肠弯曲菌作为主要的食源性病原体，在定量风险评估中备受关注。迄今为止，所有剂量反应评估都是基于一项人类喂养研究，不幸的是，该研究提供了关于剂量反应关系的不完整且可能有偏差的信息。在一家奶牛场发生的一起事件中，学校班级的几名儿童因饮用受空肠弯曲菌污染的生牛奶而患病，这似乎表明牛奶消耗量与发病率之间存在非常明显的剂量反应关系。这种关系非常接近指数形状，因此似乎与喂养研究中建立的相当缓慢上升的剂量反应关系相冲突。在这里，我们表明，当单独考虑疾病和感染时，两个数据集都可以协调一致。这不仅为弯曲杆菌的疾病剂量反应关系提供了新的信息，而且由于其条件依赖性而修正了感染剂量反应关系。
As a major foodborne pathogen, Campylobacter jejuni receives much attention in quantitative risk assessment. To date, all dose-response assessments have been based on a single human feeding study which unfortunately provides incomplete and possibly biased information on the dose-response relation. An incident at a dairy farm, where several children from a school class became ill as a result of drinking raw milk contaminated with C. jejuni, appeared to show a very clear dose-response relation between the amount of milk consumed and the attack rate. This relation was very nearly exponentially shaped and, therefore, seemed to conflict with the rather slowly rising dose-response relation established in the feeding study. Here we show that both datasets can be reconciled when illness and infection are considered separately. This not only provides new information on the illness dose-response relation for Campylobacter, but also amends the infection dose-response relation because of their conditional dependence.