Spectacular modification of Gambogic acid on microwave irradiation in methanol: isolation and structure identification of two products with potent anti-tumor activity.
Spectacular modification of Gambogic acid on microwave irradiation in methanol: isolation and structure identification of two products with potent anti-tumor activity.
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DOI：
10.1016/j.bmcl.2010.03.021
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发表时间：
2010-04
影响因子：
2.7
通讯作者：
Xiaojian Wang;N. Lu;Qian Yang;Qinsheng Dai;Lei Tao;Xiaoke Guo;Q. Guo;Q. You
中科院分区：
文献类型：
--
作者：
Xiaojian Wang;N. Lu;Qian Yang;Qinsheng Dai;Lei Tao;Xiaoke Guo;Q. Guo;Q. You
在微波辐射下，藤黄酸与甲醇在酸性条件下反应，得到两个新的产物，它们具有与报道的藤黄属天然产物不同的壮观的A环体系。这两个化合物的化学结构通过广泛的NMR和MS光谱分析以及晶体学研究进行了鉴定。两种产物均能通过凋亡途径显著抑制多种肿瘤细胞株的体外生长，IC 50值均在μM水平。
Treatment of gambogic acid with methanol in acidic condition under microwave irradiation led to the formation of two new products bearing spectacular A ring systems which were different from reported Garcinia natural products. The chemical structures of these two compounds were elucidated by extensive NMR and MS spectroscopic analysis as well as crystallographic study. Both of the two products could significantly inhibit the growth of various tumor cell lines in vitro with IC50values at μM level through apoptotic pathway.