RELATIONSHIP BETWEEN IRON DEPOSITS AND TISSUE-DAMAGE IN THE SYNOVIUM - AN ULTRASTRUCTURAL-STUDY
RELATIONSHIP BETWEEN IRON DEPOSITS AND TISSUE-DAMAGE IN THE SYNOVIUM - AN ULTRASTRUCTURAL-STUDY
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DOI：
10.1136/ard.45.1.21
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发表时间：
1986-01-01
影响因子：
27.4
通讯作者：
STEVEN, MM
中科院分区：
文献类型：
--
作者：
MORRIS, CJ;BLAKE, DR;STEVEN, MM
本文对血友病性滑膜炎（HS）、色素绒毛结节性滑膜炎（PVNS）、类风湿关节炎（RA）、骨关节炎（OA）、血清阴性炎症性关节炎（SNA）和对照组滑膜铁沉积进行了详细的超微结构研究，以探讨铁沉积与组织损伤之间的关系。电镜下，HS和PVNS患者约75%的滑膜细胞中可见铁，而RA和SNA患者仅约25%的滑膜细胞可见铁。在OA病例和控制病例中，铁矿床很少。铁通常沉积在多形性的铁体中，在HS中最常见于A型滑膜细胞。相比之下，在所有其他病例中，沉积在B型细胞中更常见，B型细胞通常是主要的细胞类型，并且脂质体更小，更均匀，更常见于滑膜组织深部。在HS病例中，滑膜A细胞中富含铁的siderosomes附近发现了相当大的组织损伤，但在其他病例中，滑膜B细胞中的这种沉积相对影响较小。我们讨论了这种差异直接反映A型和B型滑膜细胞不同功能的可能性，特别是它们在铁存在下产生具有组织破坏潜力的代谢活性氧代谢物的相对能力。
A detailed ultrastructural study was made of the synovial iron deposits in cases of haemophilic synovitis (HS), pigmented villonodular synovitis (PVNS), rheumatoid arthritis (RA), osteoarthritis (OA), seronegative inflammatory arthritis (SNA), and in controls, to investigate the relationship between iron deposits and tissue damage. Iron was seen by electron microscopy in about 75% of synovial lining cells in HS and PVNS but only in about 25% of synovial cells from cases of RA and SNA. In cases of OA and in controls iron deposits were scarce. The iron was usually deposited within pleomorphic siderosomes and in HS was most common in type A synovial cells. In contrast, deposits in all other cases were more common in type B cells, which were frequently the predominant cell type, and siderosomes were smaller, more homogeneous, and were more common in deeper synovial tissue. Considerable tissue damage was noted in the vicinity of iron rich siderosomes in synovial A cells from cases of HS, but such deposits in B cells in the synovium from the other cases had relatively little effect. We discuss the possibility that such differences directly reflect the differing functions of type A and B synovial cells, and particularly their relative ability to produce metabolically active oxygen metabolites with tissue destructive potential in the presence of iron.