Apparent diffusion coefficient measurements within intracranial epidermoid cysts in six patients
Apparent diffusion coefficient measurements within intracranial epidermoid cysts in six patients
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DOI：
10.1007/s00234-001-0726-2
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发表时间：
2002-04-01
期刊：
影响因子：
2.8
通讯作者：
Cosnard, G
中科院分区：
文献类型：
--
作者：
Annet, L;Duprez, T;Cosnard, G
目的是确定表皮样囊肿（EC）内表观扩散系数（ADC）的强烈降低是否实际上是其扩散加权（DW）迹线图像上明亮信号强度的原因。我们研究了6例经手术证实的EC患者，在这些患者中，根据T2加权DW-EPI-SE数据在EC内以及深部白色物质和脑脊液（CSF）内进行ADC计算作为参考。所有EC在DW迹线图像上显示最高信号强度。囊肿内ADC值范围为1，280至807 × 10 - 6 mm 2/s（平均值为1，070），白色物质内ADC值范围为849至698 × 10 - 6 mm 2/s（平均值为764），CSF内ADC值范围为3，370至2，980 × 10 - 6 mm 2/s（平均值为3，185）。EC表现出比白色物质略高的ADC值，而不是如果扩散加权是DW图像上EC亮信号强度的突出机制所预期的强烈降低。然而，EC ADC值远低于CSF的ADC值。因此，必须涉及其他机制，即T2穿透效应。ADC降低不是DW迹线图像上EC亮信号强度的唯一解释。
The purpose was to determine whether a strong decrease in apparent diffusion coefficient (ADC) within epidermoid cysts (ECs) is actually responsible for their bright signal intensity on diffusion-weighted (DW) trace images. We studied six patients with surgically proven ECs in whom ADC calculation from T2-weighted DW-EPI-SE data were performed within the ECs and within the deep white matter and cerebrospinal fluid (CSF) as references. All ECs displayed highest signal intensity on the DW trace images. ADC values ranged from 1,280 to 807x10(-6) mm(2)/s within cysts (with a mean value of 1,070), from 849 to 698x10(-6) mm(2)/s within white matter (with a mean value of 764) and from 3,370 to 2,980x10(-6) mm(2)/s within CSF (with a mean value of 3,185). ECs exhibited slightly higher ADC values than white matter, and not the strongly decreased ones which would have been expected if diffusion-weighting were the prominent mechanism for bright signal intensity of the ECs on DW images. However, the EC ADC values are much lower than those of the CSF. Other mechanisms must therefore be involved, i.e. the T2 shine-through effect. Reduced ADC is not the only explanation of the EC bright signal intensity on the DW trace images.