ARTIFICIAL SKIN .1. PREPARATION AND PROPERTIES OF PLURONIC F-127 GELS FOR TREATMENT OF BURNS
ARTIFICIAL SKIN .1. PREPARATION AND PROPERTIES OF PLURONIC F-127 GELS FOR TREATMENT OF BURNS
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DOI：
10.1002/jbm.820060609
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发表时间：
1972-01-01
期刊：
影响因子：
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通讯作者：
SCHMOLKA, IR
中科院分区：
文献类型：
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作者：
SCHMOLKA, IR
描述了仅衍生自环氧丙烷和环氧乙烷的嵌段聚合物表面活性剂的制备。介绍了分子量为12，500的非离子表面活性剂Pluronic F-127的物理性质。综述了聚合物系列的毒性数据。描述了F-127溶液的冷水溶液的制备，然后向其中加入银盐和其它药物。通过升高温度，这些流体液体然后被转化为强的“振铃”凝胶或粘性软膏，其适于应用于烧伤伤口或擦伤的皮肤区域。改变凝胶的屈服强度所涉及的因素。
The preparation of block polymer surface‐active agents derived solely from propylene oxide and ethylene oxide is described. The physical properties of a nonionic surfactant of 12,500 molecular weight, Pluronic F‐127, are presented. The toxicity data of the polymeric series is reviewed. The preparation of cold aqueous solutions of the F‐127 solution, to which silver salts and other medicaments are then added, is described. By raising the temperature, these fluid liquids are then converted to strong “ringing” gels or viscous ointments which are suitable for application to a burn wound or abraded skin area. The factors involved in altering the yield strength of the gel are presented.