Canals of Hering loss relates to the progression of the histological
Canals of Hering loss relates to the progression of the histological
复制标题
Hering 管丢失与组织学进展有关
DOI：
10.1136/jclinpath-2014-202417
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Nakanuma Y.
中科院分区：
文献类型：
--
作者：
Kakuda Y;Harada K;Nakanuma Y.
目的Hering管（CoH）是肝脏最外周的胆汁引流通道，被认为是肝祖细胞的小生境。最近，CoH丢失已被描述为原发性胆汁性肝硬化（PBC）的早期特征。我们调查了CoH损失和PBC的组织病理学变量之间的相关性。MethodsLiver活检标本从62例PBC患者（男：女=8：54，年龄=58±12岁）进行了评估之前熊去氧胆酸治疗。 正常肝组织（n=11）、慢性病毒性肝炎（n=36）和非酒精性脂肪性肝病（n=13）患者的肝活检组织作为对照。在个别病例中计算每个肝实质确定面积的CoH数量（c/p比值）。我们比较了PBC患者与对照组的c/p比值，并分析了与组织学变量和临床feature.ResultsThe的c/p比值在PBC患者轻度和广泛纤维化低于对照组与每个程度的纤维化。c/p比值与PBC的分期、纤维化、胆管缺失、orcein阳性颗粒沉积和肝炎活动度呈负相关（p<0.01），与肝活检组织中的碱性磷酸酶和总胆红素水平呈负相关（p<0.05）。CoH损失反映了胆汁树祖细胞供应的减少，可能参与了PBC的组织学进展。
AimsThe canals of Hering (CoH), which are the most peripherally located bile drainage pathway, are considered a niche of hepatic progenitor cells. Recently, CoH loss has been described as an early feature of primary biliary cirrhosis (PBC). We investigated the correlation between CoH loss and the histopathological variables of PBC.MethodsLiver biopsy specimens from 62 PBC patients (M:F=8:54, age=58±12 years) were evaluated prior to ursodeoxycholic acid treatment. Liver biopsies of patients with normal liver (n=11), chronic viral hepatitis (n=36) and non-alcoholic fatty liver disease (n=13) were used as controls. The number of CoH per definite area of hepatic parenchyma (c to p ratio) was calculated in individual cases. We compared the c to p ratios of PBC patients with that of controls and analysed the correlations with histological variables and clinical features.ResultsThe c to p ratios in PBC patients with mild and extensive fibrosis were lower than those in controls with each degree of fibrosis. The c to p ratios were negatively correlated with stage, fibrosis, bile duct loss, orcein-positive granule deposition and hepatitis activities in PBC (p<0.01) and with alkaline phosphatase and total bilirubin levels at liver biopsies (p<0.05).ConclusionsThe number of CoH was low in early stages and further decreased with stage progression in PBC. CoH loss, reflecting a reduced supply of progenitor cells to the biliary tree, may be involved in the histological progression of PBC.