INDOOR AIR EXPOSURE TO COAL AND WOOD COMBUSTION EMISSIONS ASSOCIATED WITH A HIGH LUNG-CANCER RATE IN XUAN-WEI, CHINA
INDOOR AIR EXPOSURE TO COAL AND WOOD COMBUSTION EMISSIONS ASSOCIATED WITH A HIGH LUNG-CANCER RATE IN XUAN-WEI, CHINA
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DOI：
10.1016/0160-4120(89)90044-5
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发表时间：
1989-01-01
影响因子：
11.8
通讯作者：
LI, XM
中科院分区：
文献类型：
--
作者：
MUMFORD, JL;CHAPMAN, RS;LI, XM
中国宣威县居民肺癌死亡率异常高，不能归因于烟草使用或职业暴露。他们暴露在未通风的露天煤矿或木柴火（通常用于烹饪和取暖）产生的烟雾中。该县各公社肺癌发病率的差异表明，室内燃烧的煤烟可能是肺癌的主要决定因素。为了描述宣威家庭的空气特征，从位于两个公社的家庭中收集了空气颗粒和半挥发性有机化合物的样本;一个公社的肺癌发病率很高，另一个公社的肺癌发病率很低。在肺癌发病率高、以无烟煤为主要燃料的社区收集的样本含有高浓度的有机物含量高的小颗粒;这些样本的有机提取物具有致突变性。从肺癌发病率较低的烧柴社区的家庭中采集的样本主要由有机物含量较低和致突变性较低的较大颗粒组成。与木材或无烟煤样品相比，无烟煤样品是小鼠皮肤致癌物，并且是皮肤肿瘤的更有效的引发剂。
Residents of Xuan Wei County in China have unusually high lung cancer mortality that cannot be attributed to tobacco use or occupational exposure. They are exposed to smoke from unvented, open pit coal or wood fires (often used for cooking and heating). The variation in lung cancer rates among communes within the county suggests that indoor combustion of smoky coal may be the prime determinant of lung cancer. To characterize the air in Xuan Wei homes, samples of air particles and semivolatile organic compounds were collected from homes located in two communes; one commune has a high rate of lung cancer, and the other has a low rate. Samples collected in the commune where the lung cancer rate is high and where smoky coal is the predominant fuel contained high concentrations of small particles with high organic content; organic extracts of these samples were mutagenic. Samples from homes in the wood-burning commune, which has a low rate of lung cancer, consisted mostly of larger particles of lower organic content and mutagenicity. The smoky coal sample was a mouse skin carcinogen and was a more potent initiator of skin tumors in comparison to the wood or smokeless coal sample.