Anxiolytic effect of essential oils of Salvia miltiorrhiza in rats.
Anxiolytic effect of essential oils of Salvia miltiorrhiza in rats.
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丹参精油对大鼠的抗焦虑作用。
DOI：
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Wu Sheng-Xi
中科院分区：
文献类型：
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作者：
Liu Ai-Dong;Cai Guo-Hong;Wei Yan-Yan;Yu Jian-Ping;Chen Jing;Yang Jing;Wang Xin;Che Yin-Wei;Chen Jian-Zong;Wu Sheng-Xi
本研究旨在探讨丁香挥发油的抗焦虑作用。丹参在大鼠体内的作用采用高架十字迷宫实验和社会交往实验评价精油的抗焦虑作用。观察了精油对大鼠大脑皮质去甲肾上腺素（NE）、多巴胺（DA）、5-羟色胺（5-HT）含量及血浆皮质酮（CORT）含量的影响。进行旋转杆测试以排除与焦虑症相关的实验程序中的任何假阳性结果。采用木僵实验研究精油是否诱发小鼠木僵。我们的研究结果表明，口服精油增加了在高架十字迷宫测试中开放臂中花费的时间百分比，并增加了进入开放臂的次数。口服精油还增加了大鼠的社交互动时间。在接受精油治疗的动物中未观察到明显的锥体外系症状（EPS）。评估了精油对培养的人神经母细胞瘤细胞中细胞内氯（Cl（-））浓度的影响。精油（50-100 mg/kg）处理后，细胞内Cl（-）浓度呈剂量依赖性增加，提示GABAA受体-Cl（-）离子通道参与其中。总之，我们的数据表明，抗焦虑作用诱导的精油从S。丹参。
This study aims to investigate the anxiolytic effects of essential oil from S. miltiorrhiza in rats. The elevated plus maze test and the social interaction test were performed to evaluate the anxiolytic effects of essential oil. The levels of noradrenaline (NE), dopamine (DA) and serotonin (5-HT) in cerebral cortex of rats as well as the plasma corticosterone (CORT) level were examined in the rats with the treatment of essential oil. The rota-rod test was carried out to exclude any false positive results in experimental procedures related to anxiety disorders. The catalepsy test was carried out to investigate whether essential oil induces the catalepsy. Our results showed that oral administration of essential oil increased the percentage of time spent in the open arms and increased the number of entries to the open arms in the elevated plus maze test. Oral administration of essential oil also increased the time for social interaction in rats. No apparent extrapyramidal symptom (EPS) was observed in the animals with essential oil treatment. The effect of essential oil in the intracellular chloride (Cl(-)) concentration in the cultured human neuroblastoma cells was assessed. Treatment with essential oil (50-100 mg/kg) increased intracellular Cl(-) concentration in the cell culture in a dose-dependent manner, suggesting the involvement of GABAA receptor-Cl(-) ion channel. Together, our data indicate an anxiolytic effect induced by the essential oil from S. miltiorrhiza.
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影响因子：
1.8
作者：
W. Setzer
通讯作者：
W. Setzer
影响因子：
7.2
作者：
Savelev, SU;Okello, EJ;Perry, EK
通讯作者：
Perry, EK
影响因子：
5
作者：
S. Yoon;Ike C Dela Peña;C. Shin;K. Son;Yong Soo Lee;J. Ryu;J. Cheong;K. Ko
通讯作者：
S. Yoon;Ike C Dela Peña;C. Shin;K. Son;Yong Soo Lee;J. Ryu;J. Cheong;K. Ko
DOI：
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发表时间：
2014-03
期刊：
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
影响因子：
--
作者：
Binyuan Yang;R. Rong;Jin Hu;Yong Yang;Qing-tao Lv;Haiqiang Jiang
通讯作者：
Binyuan Yang;R. Rong;Jin Hu;Yong Yang;Qing-tao Lv;Haiqiang Jiang
DOI：
10.1016/s0022-5223(03)00970-x
发表时间：
2003-11-01
影响因子：
6
作者：
Xia, ZY;Gu, JZ;Yu, JF
通讯作者：
Yu, JF