Chronic Chlamydia pneumoniae infection is a risk factor for the development of COPD
Chronic Chlamydia pneumoniae infection is a risk factor for the development of COPD
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DOI：
10.1016/j.rmed.2004.04.014
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发表时间：
2005-01-01
影响因子：
4.3
通讯作者：
Tornling, G
中科院分区：
文献类型：
--
作者：
Brandén, E;Koyi, H;Tornling, G
吸烟是慢性阻塞性肺疾病(COPD)发病的主要危险因素，但流行病学数据表明，其他病因因素也可能参与其中。肺炎衣原体(Cpn)是引起急性和慢性上呼吸道和下呼吸道感染的公认原因。从体外和体内研究获得的数据表明，Cpn感染可能与小气道疾病和肺气肿的发展有关，这是COPD的两个主要组成部分。本研究的目的是探讨慢性Cpn感染与慢性阻塞性肺疾病之间的可能联系。研究人群包括199名因长期呼吸道症状而接受支气管镜检查的患者，并获得肺活量测定和血清样本用于血清学检查。慢性Cpn感染，定义为持续升高的IgA滴度大于或等于1/，在85名患者中存在。慢性感染与吸烟和较高年龄有关，但没有性别差异。30例COPD患者，定义为FEV1/FVC
Smoking is the major risk factor for the development of Chronic Obstructive Pulmonary Disease (COPD), but epidemiological data suggest that other etiological factors may also be involved. Chlamydia pneumoniae (Cpn) is an established cause of acute and chronic upper and lower respiratory tract infections. Data obtained from in vitro and in vivo studies indicate that Cpn infection can be involved in the development of both small airways disease and emphysema, the two major components of COPD. The aim of this study was to investigate the possible association between chronic Cpn infection and COPD.The study population was comprised of 199 consecutive patients who underwent bronchoscopy due to longstanding airway symptoms and for whom spirometry and serum samples for serology were available.Acute and convalescent sera were analysed for specific IgG and IgA Cpn antibodies using microimmunoftuorescence. Chronic Cpn infection, defined as persistent elevated titres of IgAgreater than or equal to1/64, was present in 85 patients. Chronic infection was associated with smoking and higher age, but no gender difference was observed. Thirty patients had COPD, defined as FEV1/FVC