Effects of the Dietary Approaches to Stop Hypertension (DASH) Diet and Sodium Intake on Serum Uric Acid.
Effects of the Dietary Approaches to Stop Hypertension (DASH) Diet and Sodium Intake on Serum Uric Acid.
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DOI：
10.1002/art.39813
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发表时间：
2016-12
期刊：
影响因子：
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通讯作者：
Miller ER 3rd
中科院分区：
文献类型：
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作者：
Juraschek SP;Gelber AC;Choi HK;Appel LJ;Miller ER 3rd
指导饮食建议降低痛风的病因前体血尿酸(SUA)的随机试验数据很少。我们研究了DASH饮食(一种公认的降低血压的饮食)和钠摄入量对血尿酸的影响。我们对103名患有前期或1期高血压的成年人进行了一项随机交叉喂养试验的辅助研究。参与者被随机分配到DASH饮食或对照饮食(典型的美国饮食)，然后再按随机顺序分别喂入低、中、高钠水平30天。体重保持不变。在基线和每个喂养期之后测量尿酸。试验参与者中55%是女性，75%是黑人，平均年龄52(SD，10)岁，平均尿酸5.0(SD，1.3)mg/dL。DASH饮食降低尿酸水平为0.35 mg/dL(95%CI：−0.65，−0.05；P=0.02)，但效果更好(−1.3 mg/dL；95%CI−2.50，−0.08)，基线尿酸≥为7 mg/dL。从低钠水平增加钠摄入量，在中钠水平期间增加−0.3 mg/dL(95%CI：−0.5，−0.2；P<；0.001)，在高钠水平期间减少−0.4 mg/dL(95%CI：−0.6，−0.3；P<；0.001)。DASH饮食降低了血尿酸，这种影响在高尿酸血症参与者中更明显。此外，我们发现，较高的钠摄入量降低了血尿酸，这提高了我们对尿酸盐病理生理和高尿酸血症危险因素的了解。
Randomized trial data guiding dietary recommendations to lower serum uric acid (SUA), the etiologic precursor of gout, are scarce. We examined the effects of the DASH diet (a well-established diet that lowers blood pressure) and levels of sodium intake, on SUA. We conducted an ancillary study of a randomized, crossover feeding trial in 103 adults with pre- or stage 1 hypertension. Participants were randomly assigned to receive either the DASH diet or a control diet (typical of the average American diet) and were further fed low, medium, and high sodium levels for 30 days each in random order. Body weight was kept constant. SUA was measured at baseline and following each feeding period. Trial participants were 55% women and 75% black with a mean age of 52 (SD, 10) years and mean SUA of 5.0 (SD, 1.3) mg/dL. The DASH diet reduced SUA by −0.35 mg/dL (95%CI: −0.65, −0.05; P=0.02) with a higher effect (−1.3 mg/dL; 95% CI −2.50, −0.08) among participants (N=8) with a baseline SUA ≥7 mg/dL. Increasing sodium intake from the low level, decreased SUA by −0.3 mg/dL (95%CI: −0.5, −0.2; P<0.001) during the medium sodium level and by −0.4 mg/dL (95%CI: −0.6, −0.3; P<0.001) during the high sodium level. The DASH diet lowered SUA, and this effect was greater among participants with hyperuricemia. Moreover, we found that higher sodium intake decreased SUA, which enhances our knowledge of urate pathophysiology and risk factors of hyperuricemia.