Topical tacrolimus with different frequency for exfoliative cheilitis: a pilot study
Topical tacrolimus with different frequency for exfoliative cheilitis: a pilot study
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不同频率外用他克莫司治疗剥脱性唇炎：一项初步研究
DOI：
10.1080/09546634.2020.1771258
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发表时间：
2020-06-08
影响因子：
2.9
通讯作者：
Jiang, Wei-Wen
中科院分区：
文献类型：
--
作者：
Zhang, Qian-Qian;Xu, Pan;Jiang, Wei-Wen
摘要背景：他克莫司是一种新型免疫抑制剂。本研究的目的是评价0.1%他克莫司软膏以两种不同的频率外用治疗剥脱性唇炎的疗效。方法将40例剥脱性唇炎患者随机分为外用0.1%他克莫司软膏1次/d组和外用0.1%他克莫司软膏组1次/d。患者每天两次应用生理盐水湿敷料。治疗的有效率被定义为体征或症状改善的百分比。结果37例患者完成为期2周的治疗。并对全集进行了分析。外用0.1%他克莫司软膏缓解客观体征和主观症状的有效率在每日1次组分别为50%和67.5%。QOD组体征和症状缓解有效率分别为50%和73.5%。外用他克莫司1次/d与2天1次的疗效差异无统计学意义。结论0.1%他克莫司软膏外用1次/d和1次/2 d对剥脱性唇炎患者的体征和症状缓解具有相似的临床疗效。
Abstract Background Tacrolimus is a new type immunosuppressant. The aim of this study was to evaluate the effectiveness of topical tacrolimus 0.1% ointment at 2 different frequencies in treating patients with exfoliative cheilitis. Methods A total of 40 patients with exfoliative cheilitis were randomly divided into the QD group receiving topical tacrolimus 0.1% ointment once a day or the QOD group receiving topical tacrolimus 0.1% ointment once-two-day. Patients were also applied wet dressing of saline twice a day. The effectiveness of treatment was defined as the percentage of improvement in signs or symptoms. Results 37 patients completed the 2-week treatment. And, a full set was analyzed. The effectiveness of topical tacrolimus 0.1% ointment for relief in objective sign and subjective symptom was 50% and 67.5%% in the QD group, respectively. For the QOD group, the effectiveness of sign and symptom relief was 50% and 73.5%. There was no significant difference of effectiveness between application topical tacrolimus once a day and once 2 days. Conclusion Our data suggested that application of topical tacrolimus 0.1% ointment once a day and once 2 days had similar clinical effectiveness for sign and symptom relief in patients with exfoliative cheilitis.