Studies on Biological Activity of Cyclic Imide Compounds Part II
Studies on Biological Activity of Cyclic Imide Compounds Part II
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环状酰亚胺化合物的生物活性研究第二部分
DOI：
10.1271/bbb1961.36.318
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
Katsutoshi Tanaka
中科院分区：
文献类型：
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作者：
A. Fujinami;T. Ozaki;Katsuji Nodera;Katsutoshi Tanaka
采用琼脂稀释法研究了1-苯基吡咯烷-2，5-二酮衍生物对核盘菌的构效关系。此外，测试了几种代表性化合物对15种病原微生物的体外抗菌谱和对水稻稻瘟病、水稻褐斑病、水稻纹枯病和菜豆茎腐病的绿色室内叶面保护活性。结果表明，苯环上的3，5-二卤代取代基对油菜菌核病的抗真菌活性至关重要。通常，1-（3 '，5'-二卤代苯基）吡咯烷-2，5-二酮对皮质科、Dematiaceae、Pleosporaceae和核盘菌科具有活性，尤其对核盘菌和灰葡萄孢（Sclerotinia cinerea）（核盘菌的分生孢子形式）具有活性。N-（3，5-二氯苯基）衣康酰亚胺显示出良好的抗氧化性能。特别是抗菌谱广。在绿色室内试验中，这些化合物对水稻赤星病、水稻纹枯病和菜豆茎腐病表现出较高的活性。上述疾病的绿色室内试验结果与体外试验结果相关性较好。
The structure-activity relationships of 1-phenylpyrrolidine-2, 5-dione derivatives were investigated on Sclerotinia sclerotiorum by the agar dilution method. In addition, several representative compounds were tested for antimicrobial spectra in vitro with 15 pathogenic microbes and for foliage protection activity in green house tests with rice blast, rice brown spot, rice sheath blight and kidney bean stem rot. It was found that 3, 5-dihalo-substituents on the benzene moiety are essential to high antifungal activity against Sclerotinia sclerotiorum. Generally, 1-(3', 5'-dihalophenyl) pyrrolidine-2, 5-diones are active against Corticiaceae, Dematiaceae, Pleosporaceae and Sclerotiniaceae, especially active against Sclerotinia sclerotiorum and Botrytis cinerea (the conidia form of Sclerotinia fuckeliana). N-(3, 5-Dichlorophenyl) itaeonimide showed _??_ peculiarly broad antimicrobial spectrum. In green house tests, these compounds showed high activity against rice brown spot, rice sheath blight and kidney bean stem rot. Results of green house tests on the above-mentioned diseases correlate fairly well with those of in vitro tests.