Photo-biocatalytic One-Pot Cascades for the Enantioselective Synthesis of 1,3-Mercaptoalkanol Volatile Sulfur Compounds
Photo-biocatalytic One-Pot Cascades for the Enantioselective Synthesis of 1,3-Mercaptoalkanol Volatile Sulfur Compounds
复制标题
用于对映选择性合成 1,3-巯基烷醇挥发性硫化合物的光生物催化一锅级联
DOI：
10.1002/ange.201802135
复制
发表时间：
2018
影响因子：
--
通讯作者：
Lauder K
中科院分区：
文献类型：
--
作者：
Lauder K
描述了通过一锅光生物催化级联反应合成对映体纯1,3巯基醇挥发性硫化合物。两种新的对映体选择性相反的KRED生物催化剂被发现，并被证明在广泛的底物上有效。一锅级联反应结合光催化硫Michael加成和生物催化酮还原在水介质中提供了一种绿色和可持续的方法，以高收率获得对映体纯1,3 -巯基醇，并具有良好的对映选择性。
The synthesis of enantiomerically pure 1,3‐mercaptoalkanol volatile sulfur compounds through a one‐pot photo‐biocatalytic cascade reaction is described. Two new KRED biocatalysts with opposite enantioselectivity were discovered and proved to be efficient on a wide range of substrates. The one‐pot cascade reaction combining photocatalytic thio‐Michael addition with biocatalytic ketoreduction in an aqueous medium provides a green and sustainable approach to enantiomerically pure 1,3‐mercaptoalkanols in high yields with excellent enantioselectivity.