Epstein-Barr Virus and Human Herpesvirus 6 Detection in a Non-Hodgkin's Diffuse Large B-Cell Lymphoma Cohort by Using RNA Sequencing
Epstein-Barr Virus and Human Herpesvirus 6 Detection in a Non-Hodgkin's Diffuse Large B-Cell Lymphoma Cohort by Using RNA Sequencing
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DOI：
10.1128/jvi.02380-13
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发表时间：
2013-12-01
影响因子：
5.4
通讯作者：
Flemington, Erik K.
中科院分区：
文献类型：
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作者：
Strong, Michael J.;O'Grady, Tina;Flemington, Erik K.
来自118例非霍奇金B细胞淋巴瘤的RNA序列（RNA-seq）数据集的综合病毒组分析揭示了一个小的子集，该子集对EB病毒（EBV）或人类疱疹病毒6 B（HHV-6 B）呈阳性，其中有一种合并感染。EBV转录组分析揭示了潜伏基因RPMS 1、LMP 1和LMP 2的表达，其中一个样品另外显示出高水平的早期裂解表达，另一个样品显示出高水平的EBNA 2表达。HHV-6 B转录组分析显示，大部分基因都有转录。
Comprehensive virome analysis of RNA sequence (RNA-seq) data sets from 118 non-Hodgkin's B-cell lymphomas revealed a small subset that is positive for Epstein-Barr virus (EBV) or human herpesvirus 6B (HHV-6B), with one coinfection. EBV transcriptome analysis revealed expression of the latency genes RPMS1, LMP1, and LMP2, with one sample additionally showing a high level of early lytic expression and another sample showing a high level of EBNA2 expression. HHV-6B transcriptome analysis revealed that the majority of genes were transcribed.