Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold
Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold
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DOI：
10.1021/ol005871s
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发表时间：
2000-06-15
期刊：
影响因子：
5.2
通讯作者：
Hamilton, AD
中科院分区：
文献类型：
--
作者：
Jain, RK;Hamilton, AD
[图表]基于带有不同电荷和疏水基团的四苯基卟啉支架的受体已经合成，通过荧光光谱研究了它们与马心细胞色素c的相互作用。受体4被鉴定为细胞色素c的最强合成受体（Kd = 20 nM）。受体之间亲和力的差异反映了对阴离子和疏水基团数量的依赖性。
[GRAPHICS]Receptors based on a tetraphenylporphyrin scaffold bearing different charged and hydrophobic groups have been synthesized, The interactions of these with horse heart cytochrome c were studied by fluorescence spectroscopy. Receptor 4 was identified to be the strongest synthetic receptor (K-d = 20 nM) for cytochrome c. The differences in affinity among the receptors reflected a dependence on the number of anionic and hydrophobic groups.