The role of immunoglobulin A in endogenous bronchial defense mechanisms in chronic bronchitis.
The role of immunoglobulin A in endogenous bronchial defense mechanisms in chronic bronchitis.
复制标题
免疫球蛋白 A 在慢性支气管炎内源性支气管防御机制中的作用。
DOI：
10.1164/arrd.1971.103.6.784
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发表时间：
1971
期刊：
影响因子：
--
通讯作者：
H. Buergi
中科院分区：
文献类型：
--
作者：
T. Medici;H. Buergi
本文探讨了分泌型免疫球蛋白A（11S伊加）在慢性支气管炎反复感染中的作用。以痰液中乳酸脱氢酶、脱氧核糖核酸纤维和纤维蛋白原浓度作为炎症指标，痰液中伊加含量与支气管上皮损伤和炎症程度有关。轻度至中度支气管炎患者的痰中伊加含量的短期显着增加的结果，炎症产生的刺激，而严重的，长期晚期支气管炎患者未能显示出这种反应。免疫扩散研究表明，在后者患者的分泌“片”是缺席的痰。因此，我们推测，由于支气管上皮的损伤，分泌“碎片”的产生部分或全部受到干扰。因此，免疫活性11S分泌伊加的合成受损。如果没有这个…
Investigations were carried out to evaluate the role of secretory immunoglobulin A (11S IgA) in the recurrent infections of chronic bronchitis. The IgA content in sputum was related to damage of the bronchial epithelium and the degree of inflammation using the concentrations of lactic dehydrogenase, deoxyribonucleic acid fibers, and fibrinogen in the sputum as criteria of inflammation. The IgA content in sputum of patients with mild to moderate bronchitis of short duration increased significantly as a result of an inflammation-producing stimulus whereas patients with severe, far advanced bronchitis of long duration failed to show this response. Immunodiffusion studies suggested that in the latter patients the secretory “piece” was absent from the sputum. It is therefore assumed that the production of the secretory “piece” was partially or totally disturbed due to the damage of the bronchial epithelium. Consequently, the synthesis of immunologically active 11S secretory IgA was impaired. The absence of thi...