Atherogenic Index of Plasma Is an Independent Risk Factor for Coronary Artery Disease and a Higher SYNTAX Score
Atherogenic Index of Plasma Is an Independent Risk Factor for Coronary Artery Disease and a Higher SYNTAX Score
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DOI：
10.1177/0003319720949804
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发表时间：
2020-08-20
期刊：
影响因子：
2.8
通讯作者：
Zijie, Li
中科院分区：
文献类型：
--
作者：
Wang, Luzhao;Chen, Fangyao;Zijie, Li
我们的目的是确定血浆致动脉粥样硬化指数（AIP）对冠状动脉疾病（CAD）的最佳诊断临界值及其与SYNTAX评分（SS）的相关性。2016年1月至2019年12月，2253例CAD患者和1347例数据完整的非CAD患者被纳入研究。使用Judkins技术进行冠状动脉造影，并使用网络软件计算SS。年龄、体重指数、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平和AIP在组间存在差异（均P <0.01）。多因素Logistic回归分析显示，AIP是冠心病的独立危险因素，是高SS（SS ≥ 23）的危险因素，每增加一个标准差，校正比值比分别为2.248（95%CI：1.666- 3.032，P <0.01）和1.623（95%CI：1.118- 2.358，P <0.01）。受试者工作特征曲线分析显示，AIP预测冠心病和SS ≥ 23的最佳诊断界值分别为2.035和2.23，特异性分别为61.8%和65.7%，敏感性分别为76.4%和54.9%，Youden指数分别为0.382和0.206，曲线下面积分别为0.733（95%CI：0.717- 0.750，P <0.01）和0.653（95%CI：0.630- 0.676，P <0.01）。血浆致动脉粥样硬化指数作为一种生物标志物，可能有助于中国人群冠心病的预防。
We aimed to identify the best diagnostic cutoff value of the atherogenic index of plasma (AIP) for coronary artery disease (CAD) and its correlation with the SYNTAX score (SS). From January 2016 to December 2019, 2253 patients with CAD and 1347 non-CAD patients with complete data were included in the study. Coronary angiography was performed using the Judkins technique, and the SS was calculated using network software. There were differences in age, body mass index, total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol levels, and AIP between groups (allP< .01). Multivariate logistic regression analysis showed that AIP was an independent risk factor for CAD and a high SS (SS >= 23) with adjusted odds ratios of 2.248 (95% CI: 1.666-3.032,P< .01) and 1.623 (95% CI: 1.118-2.358,P< .01) per standard deviation increase. Receiver operating characteristic curve analysis revealed that the best diagnostic cutoff value of AIP for the prediction of CAD and SS >= 23 was 2.035 and 2.23, the specificity was 61.8% and 65.7%, the sensitivity was 76.4% and 54.9%, the Youden index was 0.382 and 0.206, and the area under the curve was 0.733 (95% CI: 0.717-0.750,P< .01) and 0.653 (95% CI: 0.630-0.676,P< .01). Atherogenic index of plasma, as a biomarker, may assist in the prevention of CAD in the Chinese population.