Serial levels of serum organochlorines during pregnancy and postpartum
Serial levels of serum organochlorines during pregnancy and postpartum
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DOI：
10.1080/00039899909602244
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发表时间：
1999-03-01
期刊：
影响因子：
--
通讯作者：
Berendes, HW
中科院分区：
文献类型：
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作者：
Longnecker, MP;Klebanoff, MA;Berendes, HW
在子宫内接触二氯二苯二氯乙烯和多氯联苯（在美国一般人群中发现的范围内）可能会对后代产生可检测到的影响。为了设计子宫内有机氯暴露影响的研究，我们获得了妊娠期和围产期母体水平之间的关系，在几个场合的女性数据。我们研究了67名美国孕妇，她们同意在每个三个月和产后抽血一次。我们检查了水平（μ g/g血清脂质）的自然对数之间的Pearson相关系数。对于二氯二苯二氯乙烯和多氯联苯，孕早期和孕晚期的相关系数r分别为0.86和0.77。在其他时间确定的水平之间的相关性（即，孕中期和产后）相似。根据这些结果，我们建议，在子宫内或围产期暴露于上述化合物的影响的研究中，标本收集的时间并不重要。
In utero exposure to dichlorodiphenyldichloroethene and polychlorinated biphenyls, within the range found in the general U.S. population, may produce detectable effects in offspring. To design studies of the effects of in utero organochlorine exposure, we obtained data on the relationship between gestational and perinatal maternal levels in females on several occasions. We studied 67 pregnant women in the United States who agreed to have their blood drawn once during each trimester and once postpartum. We examined the Pearson correlation coefficient between the natural logarithm of levels (mu g/g serum lipid). The correlation, r, among revels in the first and third trimester was .86 and .77 for dichlorodiphenyldichloroethene and for polychlorinated biphenyls. Correlations among levels determined at other times (i.e., second trimester and postpartum) were similar. On the basis of these results, we suggest that in studies of the effects of in utero or perinatal exposure to the aforementioned compounds, the time when specimens are collected is not critical.