HD39 (B3), a B lineage-restricted antigen whose cell surface expression is limited to resting and activated human B lymphocytes.
HD39 (B3), a B lineage-restricted antigen whose cell surface expression is limited to resting and activated human B lymphocytes.
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HD39 (B3)，一种 B 谱系限制性抗原，其细胞表面表达仅限于静息和活化的人 B 淋巴细胞。
作者：
B. Dörken;G. Moldenhauer;A. Pezzutto;R. Schwartz;A. Feller;S. Kiesel;Lee M. Nadler
本报告描述了 B 细胞限制性抗原 HD39，其细胞表面表达仅限于静息和活化的人 B 淋巴细胞。单克隆抗体 HD39 可检测表观分子量为 130,000 和 140,000 的双链糖蛋白。在 B 细胞个体发育过程中，HD39 首先在骨髓来源的前 B 细胞的细胞质中表达，然后出现在 sIgM+ B 细胞的细胞表面上，最后出现在大多数 sIgM+ sIgD+ 静息 B 细胞上。体外激活后，HD39在细胞表面的表达首先增加，然后随着细胞开始分化，抗原丢失。 HD39 在极少数非 T 细胞 ALL 和 B 细胞 CLL 以及大约 50% 的 B 细胞淋巴瘤中呈弱表达，而在华氏巨球蛋白血症和骨髓瘤中则不表达。相反，它在所有毛细胞白血病中强烈表达。它在 B 细胞个体发育中有限的细胞表面表达表明 HD39 在调节人类静息 B 淋巴细胞激活的事件中可能很重要。
The B cell-restricted antigen HD39, whose cell surface expression is limited to resting and activated human B lymphocytes, is described in this report. The monoclonal antibody HD39 detects a two-chain glycoprotein with apparent molecular weights of 130,000 and 140,000. During B cell ontogeny, HD39 is first expressed in the cytoplasm of bone marrow derived pre-B cells, then appears on the cell surface of sIgM+ B cells, and finally on the majority of sIgM+ sIgD+ resting B cells. After activation in vitro, the expression of HD39 on the cell surface first increases, and then the antigen is lost as cells begin to differentiate. HD39 is weakly expressed on very few non-T cell ALL and B cell CLL, on approximately 50% of B cell lymphomas, and not on Waldenström's macroglobulinemias and myelomas. In contrast, it is strongly expressed on all hairy cell leukemias. Its limited cell surface expression in B cell ontogeny suggests that HD39 may be important in the events that regulate the activation of the human resting B lymphocytes.