Prefrontal neural correlates of memory for sequences
Prefrontal neural correlates of memory for sequences
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DOI：
10.1523/jneurosci.4483-06.2007
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发表时间：
2007-02-28
影响因子：
5.3
通讯作者：
Lee, Daeyeol
中科院分区：
文献类型：
--
作者：
Averbeck, Bruno B.;Lee, Daeyeol
解决一个问题的适当行动顺序往往需要通过试错来发现，并在未来面临同样的问题时回忆起来。在这里，我们表明，当猴子不得不发现并记住一系列决定时，前额叶皮层神经元的集合反映了动物在整个试验间隔期间所做的决定的顺序。这个信号可以反映一个明确的记忆过程，也可以反映一个在实际序列执行之前很久就开始的序列规划过程。这一发现延伸到错误试验中，当试验间隔期间的神经活动指定了错误的序列时，动物也试图执行错误的序列。更具体地说，我们使用解码分析来预测猴子计划在前阶段结束时执行的序列，就在序列执行之前。当这种分析应用于错误试验时，我们能够预测错误将在序列中发生的位置，最多可以预测未来的三个运动。这表明，前额叶神经活动可以保留关于试验之间序列的信息，并且无论信息是正确还是错误地记住，前额叶活动都真实地反映了动物的行动计划。
The sequence of actions appropriate to solve a problem often needs to be discovered by trial and error and recalled in the future when faced with the same problem. Here, we show that when monkeys had to discover and then remember a sequence of decisions across trials, ensembles of prefrontal cortex neurons reflected the sequence of decisions the animal would make throughout the interval between trials. This signal could reflect either an explicit memory process or a sequence-planning process that begins far in advance of the actual sequence execution. This finding extended to error trials such that, when the neural activity during the intertrial interval specified the wrong sequence, the animal also attempted to execute an incorrect sequence. More specifically, we used a decoding analysis to predict the sequence the monkey was planning to execute at the end of the fore-period, just before sequence execution. When this analysis was applied to error trials, we were able to predict where in the sequence the error would occur, up to three movements into the future. This suggests that prefrontal neural activity can retain information about sequences between trials, and that regardless of whether information is remembered correctly or incorrectly, the prefrontal activity veridically reflects the animal's action plan.