Mapping of T1-Values and Gadolinium-Concentrations in MRI as Indicator of Disease Activity in Luminal Crohn's Disease: A Feasibility Study
Mapping of T1-Values and Gadolinium-Concentrations in MRI as Indicator of Disease Activity in Luminal Crohn's Disease: A Feasibility Study
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DOI：
10.1002/jmri.21535
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发表时间：
2009-02-01
影响因子：
4.4
通讯作者：
Stoker, Jaap
中科院分区：
文献类型：
--
作者：
Horsthuis, Karin;Nederveen, Aart J.;Stoker, Jaap
目的：探讨肠内克罗恩病（CD） t1定位及钆值计算的可行性。材料与方法：纳入9例活动性CD患者。根据内窥镜和组织病理学结果确定每个患者的疾病活动。同时测定克罗恩病内镜下严重程度指数（CDEIS）、Harvey-Bradshaw指数（HBI）和c反应蛋白（CRP）作为参考标准。使用Look-Locker （LL）序列结合分段三维Turbo Field Echo序列，在单次屏住呼吸的情况下，对14片静脉注射Gadodiamide前后进行t1测量。在炎症肠袢周围画一个感兴趣区域（ROI），并计算ROI内的平均钆浓度。根据参考标准，比较轻度和明显疾病患者之间的钆浓度。结果：根据内镜和组织病理学检查、CRP和HBI的定义，疾病更活跃的患者肠袢中的平均钆浓度更高。结论：通过在肠道中使用屏气LL序列来定量评估造影剂浓度是可能的，从而可以客观地评估运动问题区域活跃炎症组织的生理变化。
Purpose: To determine the feasibility of T1-mapping and calculation of Gadolinium-values in luminal Crohn's Disease (CD).Materials and Methods: Nine patients with active CD were included. For each patient disease activity was determined, based on endoscopic and histopathological results. The Crohn's Disease Endoscopic Index of Severity (CDEIS), the Harvey-Bradshaw index (HBI) and C-reactive protein (CRP) were also determined as reference standards. T1-measurements were performed before and after intravenous administration of Gadodiamide in 14 slices in a single breath-hold using the Look-Locker (LL) sequence in combination with a segmented three-dimensional Turbo Field Echo sequence. A Region of Interest (ROI) was drawn around inflamed bowel loops and the mean Gadolinium-concentration within the ROI was calculated. Gadolinium-concentrations were compared between patients with mild and marked disease, as determined by the reference standards.Results: Mean Gadolinium-concentrations were higher in bowel loops of patients with more active disease, as defined by endoscopic and histopathological examination, CRP, and HBI.Conclusion: By using a breath-hold LL sequence in the bowel quantitative assessment of contrast agent concentration is possible, thus permitting objective evaluation of physiological changes in actively inflamed tissue in an area that suffers from motion problems.