The ratio of serum transferrin receptor and serum ferritin in the diagnosis of iron status
The ratio of serum transferrin receptor and serum ferritin in the diagnosis of iron status
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DOI：
10.1046/j.1365-2141.2001.03063.x
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发表时间：
2001-10-01
影响因子：
6.5
通讯作者：
Hiss, DC
中科院分区：
文献类型：
--
作者：
Malope, BI;MacPhail, AP;Hiss, DC
用于诊断铁状态的实验室检查在定义缺铁性贫血（IDA）和炎症性贫血（Al）方面缺乏特异性。血清转铁蛋白受体（sTfR）可能提供更多的信息在这方面。采用常规方法对561名学龄前儿童的铁营养状况进行了测定和分类。通过比较sTfR浓度、sTfR（μ g/ml）与LogSF（μ g/l）的比值（TfR-指数）以及sTfR（μ g/l）与SF（μ g/l）比值的对数-（LogTfR：Fer比值）在铁状态分类中的分布，确定了它们在铁状态分类中的值。虽然有显着差异，在sTfR和TfR指数的铁状态的类别，有相当大的重叠。所有患有铁缺乏症的受试者的LogTfR：Fer比率> 2.55，而在所有被归类为AI的受试者中，LogTfR：Fer比率< 2.55，从而清楚地将两者分开。LogTfR：Fer比值不能排除存在炎症的IDA。然而，在HA和Al组合的情况下，炎症消退后LogTfR：Fer比率为2.55。这种计算LogTfR：Fer比值的新方法可以提供儿童铁状况的更精确分类。
Laboratory tests used in the diagnosis of iron status lack specificity in defining iron deficiency anaemia (IDA) and anaemia of inflammation (Al). The serum transferrin receptor (sTfR) may provide more information in this regard. The iron status of 561 pre-school children was determined and classified using the conventional measurements. The value of the concentration of sTfR, the ratio of sTfR (mug/ml) to LogSF (mug/l) (TfR-Index), and the Log of the ratio of sTfR (mug/l) to SF (mug/l) - (LogTfR:Fer ratio), in the classification of the iron status were determined by comparing their distributions across the classification of iron status. Although there were significant differences in sTfR and TfR-Index across the categories of iron status, there was considerable overlap. All subjects with iron deficiency had LogTfR:Fer ratio > 2.55, whereas in all subjects classified as AI it was < 2.55, thus clearly separating the two. The LogTfR:Fer ratio was not able to exclude IDA in the presence of inflammation. However, in cases of combined HA and Al the LogTfR:Fer ratio was 2.55 after resolution of the inflammation. This novel method of calculating the LogTfR:Fer ratio may provide a more precise classification of the iron status of children.