The structural basis for the sensing and binding of cyclic di-GMP by STING
The structural basis for the sensing and binding of cyclic di-GMP by STING
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DOI：
10.1038/nsmb.2333
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发表时间：
2012-07-01
影响因子：
16.8
通讯作者：
Su, Xiao-Dong
中科院分区：
文献类型：
--
作者：
Huang, Yi-He;Liu, Xiang-Yu;Su, Xiao-Dong
STING（干扰素基因刺激因子）是一种重要的信号转接器，通过直接感知细菌的次级信使，如环二核苷酸双-(3'-5')-环二聚体GMP (c-di-GMP)，介导细胞因子的产生，以应对微生物的入侵。STING的结构及其与环二核苷酸的结合机制尚不清楚。我们报道了STING细胞质结构域及其与c-di-GMP复合物的晶体结构，从而为理解STING功能提供了结构基础。
STING (stimulator of interferon genes) is an essential signaling adaptor that mediates cytokine production in response to microbial invasion by directly sensing bacterial secondary messengers such as the cyclic dinucleotide bis-(3'-5')-cyclic dimeric GMP (c-di-GMP). STING's structure and its binding mechanism to cyclic dinucleotides were unknown. We report here the crystal structures of the STING cytoplasmic domain and its complex with c-di-GMP, thus providing the structural basis for understanding STING function.