Chemotaxis in pathogenic spirochetes: directed movement toward targeting tissues?
Chemotaxis in pathogenic spirochetes: directed movement toward targeting tissues?
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DOI：
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发表时间：
2000-10
影响因子：
1.2
通讯作者：
R. Lux;A. Moter;W. Shi
中科院分区：
文献类型：
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作者：
R. Lux;A. Moter;W. Shi
趋化性是能动生物的一个重要特征，可以在各种环境中导航。它使它们能够检测营养物质并避免不利或危险的条件。运动性和趋化性被广泛认为是致病菌的重要毒力因子。本文就趋化性在螺旋体致病中的作用作一综述。趋化性可能参与组织识别和渗透，并代表了逃避宿主免疫防御的可能机制。最近发展的遗传工具致病螺旋体和“跟踪”技术，采用荧光原位杂交（FISH），可能会彻底改变我们的理解的重要性，感染和持久性的这些细菌在其主机的趋化性。
Chemotaxis is an important feature of motile organisms that allows navigation through various environments. It enables them to detect nutrients and to avoid unfavorable or dangerous conditions. Motility and chemotaxis are widely acknowledged as important virulence factors for pathogenic bacteria. In this review, we try to explore the role of chemotaxis in the pathogenesis of spirochetes. Chemotaxis might be involved in tissue identification and penetration, and represents a possible mechanism for evasion of the host's immune defense. The recent development of genetic tools for pathogenic spirochetes and "tracking" techniques, employing fluorescent in situ hybridization (FISH), could revolutionize our understanding of the importance of chemotaxis for infection and persistence of these bacteria in their host.