THE SUPPRESSION OF PINEAL MELATONIN CONTENT AND N-ACETYLTRANSFERASE ACTIVITY BY DIFFERENT LIGHT IRRADIANCES IN THE SYRIAN-HAMSTER - A DOSE-RESPONSE RELATIONSHIP
THE SUPPRESSION OF PINEAL MELATONIN CONTENT AND N-ACETYLTRANSFERASE ACTIVITY BY DIFFERENT LIGHT IRRADIANCES IN THE SYRIAN-HAMSTER - A DOSE-RESPONSE RELATIONSHIP
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DOI：
10.1210/endo-113-1-293
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发表时间：
1983-01-01
期刊：
影响因子：
4.8
通讯作者：
REITER, RJ
中科院分区：
文献类型：
--
作者：
BRAINARD, GC;RICHARDSON, BA;REITER, RJ
本文研究了不同强度冷白光对金黄地鼠松果体N-乙酰转移酶（NAD）活性和褪黑素含量的影响。在夜间将动物组暴露于范围为0.000-1.86 μ W/cm 2的光辐照度20分钟。松果体NAT和黑素类似地被抑制的光辐照度在剂量相关的方式。NAT（0.066 μ W/cm 2）和褪黑激素（0.058 μ W/cm 2）的所得剂量-响应曲线的形状和计算的ED 50非常相似。这些发现可能与自然光照对松果体的生理控制有关。
The influence of various irradiances of cool while fluorescent light on the suppression of pineal N-acetyltransferase activity (NAD) and melatonin content in hamsters was tested. Groups of animals were exposed to light irradiances ranging from 0.000-1.86 .mu.W/cm2 for 20 min during the night. Both pineal NAT and melantonin were similarly depressed by the light irradiances in a dose-related manner. The shape of the resultant dose-response curves and the calculated ED50 for NAT (0.066 .mu.W/cm2) and melatonin (0.058 .mu.W/cm2) were remarkably similar. These findings may be relevant to the physiological control of the pineal by natural illumination.