Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist
Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist
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DOI：
10.1111/j.0022-202x.2004.22305.x
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发表时间：
2004-03-01
影响因子：
6.5
通讯作者：
Nicklin, MJH
中科院分区：
文献类型：
--
作者：
Shepherd, J;Little, MC;Nicklin, MJH
白细胞介素-1受体拮抗剂缺乏（II1rn-/-） BALB/c小鼠在64%的病例中发生局部耳膜皮肤炎症。组织病理学上，该疾病具有许多与人类牛皮癣相似的特征，表明它可能是一种有用的疾病模型。表皮增厚增厚，表达未成熟角蛋白K6。角质层呈角化不全。大的表皮突出形成粗增厚的真皮，两种组织均有白细胞浸润。角质层下形成富含中性粒细胞的微脓肿。在真皮和表皮中都发现了树突状细胞和活化的T细胞，而在真皮中发现了高密度的巨噬细胞，其中肥大细胞也很突出。病变真皮可见明显活化的致密小血管。皮肤炎症，以及动脉炎症和关节炎，是第三种被发现影响II1rn-/- BALB/c小鼠的部位特异性炎症性疾病。没有一种疾病影响II1rn-/- C57BL/6。在II1rn-/- BALB/c和C57BL/6的F2杂交种中，没有皮肤炎症，主动脉炎症常见，关节炎罕见，这表明导致每种疾病易感性的背景修饰基因组并没有完全重叠。
Interleukin-1 receptor antagonist-deficient (II1rn-/-) BALB/c mice developed inflammation localized to the skin of the ear pinna in 64% of the cases examined. Histopathologically, the disease had many features resembling human psoriasis, suggesting that it might be a useful disease model. The epidermis became thickened and hypertrophic, and expressed the immature keratin, K6, throughout. The stratum corneum showed parakeratotsis. Large epidermal projections formed into a grossly thickened dermis and both tissues were infiltrated by leukocytes. Neutrophil-rich microabscesses formed beneath the stratum corneum. Dendritic cells and activated T cells of both helper classes were identified in both the dermis and epidermis, while a high density of macrophages was seen in the dermis, where mast cells were also prominent. Dense patterns of apparently activated small dermal vessels were seen in the diseased dermis. Cutaneous inflammation, along with arterial inflammation and arthritis, is the third site-specific, inflammatory disease to be found to affect II1rn-/- BALB/c mice. None of the diseases affected II1rn-/- C57BL/6. In F2 hybrids of II1rn-/- BALB/c and C57BL/6, cutaneous inflammation was absent, aortic inflammation was common, and arthritis was rare, indicating that the sets of background modifier genes that cause susceptibility to each disease are not fully overlapping.