Positron emission tomography with [18F]flutemetamol and [11C]PiB for in vivo detection of cerebral cortical amyloid in normal pressure hydrocephalus patients
Positron emission tomography with [18F]flutemetamol and [11C]PiB for in vivo detection of cerebral cortical amyloid in normal pressure hydrocephalus patients
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DOI：
10.1111/ene.12102
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发表时间：
2013-07-01
影响因子：
5.1
通讯作者：
Grachev, I. D.
中科院分区：
文献类型：
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作者：
Leinonen, V.;Rinne, J. O.;Grachev, I. D.
背景和目的本研究通过免疫组织化学和组织化学染色在额叶皮质活检中测定淀粉样蛋白正电子发射断层扫描（PET）显像剂[18 F] flutemetaline和淀粉样蛋白摄取之间的相关性。方法对15例有颅内压监测脑活检史的正常压力脑积水（NPH）患者进行18F正电子发射计算机断层扫描（PET）。其中7例患者还接受了[11 C]匹兹堡化合物B（PiB）PET。使用标准化摄取值比率（SUVR）定量[18 F] Flutemetaline和[11 C]PiB摄取，小脑皮质作为参考区域。组织淀粉样蛋白-使用单克隆抗体4G 8、硫磺素-S和Bielschowsky银染色进行评价。结果[18F] Flutemetaminase和[11 C]PiB SUVR与对侧活检标本淀粉样蛋白水平相关（r=0.86，P
Background and purpose This study determined the correlation between uptake of the amyloid positron emission tomography (PET) imaging agent [18F]flutemetamol and amyloid- measured by immunohistochemical and histochemical staining in a frontal cortical biopsy. Methods Fifteen patients with possible normal pressure hydrocephalus (NPH) and previous brain biopsy obtained during intracranial pressure monitoring underwent [18F]flutemetamol PET. Seven of these patients also underwent [11C] Pittsburgh compound B (PiB) PET. [18F]Flutemetamol and [11C]PiB uptake was quantified using standardized uptake value ratio (SUVR) with the cerebellar cortex as a reference region. Tissue amyloid- was evaluated using the monoclonal antibody 4G8, Thioflavin-S and Bielschowsky silver stain. Results [18F]Flutemetamol and [11C]PiB SUVRs correlated with biopsy specimen amyloid- levels contralateral (r=0.86, P