Analyzing Chinese Patients with Post-Operative Acute Kidney Injury
Analyzing Chinese Patients with Post-Operative Acute Kidney Injury
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DOI：
10.3109/0886022x.2011.601827
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发表时间：
2011-08
期刊：
影响因子：
3
通讯作者：
Wen Zhang;P. Shen;Yongxi Chen;P. Zhu;Hao Shi;Xiao Li;Yaowen Xu;H. Ren;N. Chen
中科院分区：
文献类型：
--
作者：
Wen Zhang;P. Shen;Yongxi Chen;P. Zhu;Hao Shi;Xiao Li;Yaowen Xu;H. Ren;N. Chen
摘要背景：探讨中国术后急性肾损伤（PO-AKI）患者的临床特点及危险因素。方法：对1997年12月~ 2005年12月瑞金医院PO-AKI患者进行回顾性分析。结果：患者平均年龄62.2±18.1岁。男性111人，女性57人。诊断时血清肌酐平均值为370.41±320.92 μmol/L，肾小球滤过率平均值为33.56±24.24 mL/min。死亡38例，死亡率为22.6%。17例患者（10.1%）为急性透析质量主动性-步枪（风险-损伤-失败-损失结束分类）R期，21例患者（12.5%）为I期，130例患者（77.4%）为f期。接受不同类型手术的患者死亡率无显著差异。对于与PO-AKI相关的危险因素，急性肾小管坏死（ATN）增加了PO-AKI死亡的相对风险（优势比= 7.089,95%可信区间= 2.069-24.288,p < 0.001）。多因素回归模型显示ATN与PO-AKI死亡率呈正相关。结论：PO-AKI是手术患者AKI最常见的原因之一。应特别注意与PO-AKI相关的危险因素，以改善预后。
Abstract Background: To investigate clinical characteristics and risk factors of Chinese patients with post-operative acute kidney injury (PO-AKI). Methods: Patients with PO-AKI in Ruijin Hospital from December 1997 to December 2005 were retrospectively studied. Results: Patients’ mean age was 62.2 ± 18.1 years. There were 111 males and 57 females. The mean serum creatinine at diagnosis was 370.41 ± 320.92 μmol/L and the mean estimated glomerular filtration rate was 33.56 ± 24.24 mL/min. For the outcome of the patients, 38 died and the mortality rate was 22.6%. There were 17 patients (10.1%) with Acute Dialysis Quality Initiative-RIFLE (risk-injury-failure-loss-end classification) phase R, 21 (12.5%) with phase I, and 130 (77.4%) with phase F. There was no significant difference in mortality regarding patients who underwent different types of surgeries. For the risk factors related to PO-AKI, acute tubular necrosis (ATN) increased relative risk of mortality PO-AKI (odds ratio = 7.089, 95% confidence interval = 2.069–24.288, p < 0.001). Multivariate regression models showed that ATN had a positive correlation with mortality of PO-AKI. Conclusions: PO-AKI is one of the most common causes of AKI in patients who underwent operations. Special attention should be paid to risk factors related to PO-AKI in order to improve prognosis.