A blood pump with an interatrial shunt for use as an electrohydraulic total artificial heart.
A blood pump with an interatrial shunt for use as an electrohydraulic total artificial heart.
复制标题
带有心房分流器的血泵，用作电动液压全人工心脏。
DOI：
10.1097/00002480-199207000-00069
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Olsen,DB
中科院分区：
文献类型：
--
作者：
Tatsumi,E;Diegel,PD;Holfert,JW;Dew,PA;Crump,KR;Hansen,AC;Khanwilkar,PS;Rowles,JR;Olsen,DB
一种用于完全植入式电液全人工心脏（EHTAH）的血泵子系统已被开发并正在评估中。该子系统包括连接的左右心室，带有房间分流（IAS）的心房袖口和两个流出移植物。根据解剖拟合试验的结果，心室发育成适合于心包间隙。确定了一种适合动物使用的优化配置，该配置在最小的修改下适用于人类使用。带能量转换器的心室核心尺寸约为10x11x7cm。最大输出和冲程体积分别为9.2 L/min和81 ml。IAS用于平衡体积耦合的EHTAH，并通过在左心房和右心房袖带的共同间隔形成一个孔而制成。在长达9天的动物实验中检验了IAS的性能和耐久性。IAS直径3.4-5.5 mm，左右心房压差2 - 10 mmHg，理论计算分流流量0.57-1.48 L/min。尸检时未发现IAS内部或周围有血栓形成的证据。整个EHTAH系统与一个新的血泵正在组装长期的动物研究。
A recently designed blood pump subsystem for the completely implantable electrohydraulic total artificial heart (EHTAH) has been developed and is under evaluation. The subsystem consists of joined left and right ventricles, atrial cuffs with an interatrial shunt (IAS), and two outflow grafts. The ventricles were developed to fit within the pericardial space based on the results of anatomic fit trials. An optimized configuration for animal use, which was adaptable for human use with minimal modification, was identified. The core dimensions of the ventricles with an energy converter are approximately 10× 11× 7 cm. Maximum output and stroke volume are 9.2 L/min and 81 ml, respectively. The IAS is used to balance the volumetrically coupled EHTAH, and is made by forming an orifice in the common septum of the left and right atrial cuffs. Performance and durability of the IAS were examined in animal experiments for up to 9 days. The diameter of the IAS was 3.4–5.5 mm, and the left-right atrial pressure difference ranged from 2 to 10 mmHg, with 0.57–1.48 L/min of theoretically calculated shunt flow. No evidence of thrombus formation was found in or around the IAS at autopsy. The entire EHTAH system with a new blood pump is being assembled for long-term animal studies.